MPL anticorps

N° du produit ABIN1105749

Cet anticorps anti-MPL est un anticorps Souris Monoclonal détectant MPL dans WB, FACS et EIA. Adapté pour Humain.

Aperçu rapide pour MPL anticorps (ABIN1105749)

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MPL est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: 1H2

Détail du produit anti-MPL anticorps

Specificité: Recognizes MPL/CD110

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Purified

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, 0.05 % Sodium Azide, 0.5 % protein stabilizer

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Détails sur MPL

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: CD110

Sujet: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.Synonyms: MPL, Myeloproliferative leukemia protein, TPO-R, TPOR

Poids moléculaire: 71.2 kDa

ID gène: 4352

Pathways: Signalistation JAK/STAT