CD130/gp130 anticorps

N° du produit ABIN1105843

Cet anticorps Hamster Monoclonal détecte spécifiquement CD130/gp130 dans FACS et EIA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour CD130/gp130 anticorps (ABIN1105843)

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivité: Humain, Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp CD130/gp130 est non-conjugé

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: HMb1

Détail du produit anti-CD130/gp130 anticorps

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Protein G agarose

Immunogène: Mouse CD130 transfected 293T cells

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store (in aliquots) at -20 °C.

Détails sur CD130/gp130

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Autre désignation: CD130 / IL6ST

Sujet: The interleukin-6 (IL-6) cytokine family, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and B-cell stimulatory factor 3, are also known as gp130 cytokines because they all share gp130 as a common transducer protein within their functional receptor complexes. In the case of IL-6, binding of the ligand to its specific a-receptor (IL-6Ra/CD126) induces dimerization of gp130, activation of the gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain-containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the suppressor of cytokine signaling 3 (SOCS3). The subsequently tyrosine phosphorylated STAT homo- or heterodimers translocate to the nucleus where they bind to enhancer sequences of IL-6-inducible genes. Both IL-6Ra and gp130 have soluble forms. Although soluble gp130 inhibits the effect of IL-6, the soluble IL-6Ra promotes the effect of IL-6.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta

ID gène: 10090

UniProt: Q00560

Pathways: Signalistation JAK/STAT, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints