CD40 Ligand anticorps (FITC)

N° du produit ABIN1105907

L’anticorps anti-CD40 Ligand Monoclonal produit chez le Souris a été validé pour FACS. Il convient pour la détection de CD40 Ligand dans des échantillons provenant de Humain. }

Aperçu rapide pour CD40 Ligand anticorps (FITC) (ABIN1105907)

Antigène: CD40 Ligand (CD40LG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD40 Ligand est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Clone: 5F3

Détail du produit anti-CD40 Ligand anticorps (FITC)

Specificité: This antibody reacts with CD154 antigen.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogène: Human CD154 transfected 300-19 cell (mouse pre-B cell line)

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 10 mM NaPB ( pH 8.0), 0.15 M NaCl, 0.09 % NaN3, 1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur CD40 Ligand

Antigène: CD40 Ligand (CD40LG)

Autre désignation: CD154 / CD40L

Sujet: The human CD154 (CD40-ligand) is a 39 kDa type II membrane glycoprotein predominantly expressed on CD4+ T cells, but also on a small proportion of CD8+ cells and NK cells. It is belonging to the tumor necrosis factor (TNF) family, while its counterreceptor on B cells, CD40, is a member of the TNF receptor/nerve growth factor (NGF) receptor family. Interactions between CD40 on B cells and its ligand on activated T cells results in B cell activation, proliferation, aggregation, and immunoglobulin isotype switching. A defect in the gene encoding CD154 is responsible for X-linked immunoglobulin deficiency with normal or elevated IgM (X-linked hyper IgM). These patients produce IgM but fail to produce downstream Ig isotypes, suggesting that interaction between CD40 on B cells and its ligand on activated T cells plays a critical role in Ig heavy chain switch recombination. The expression of CD154 on activated T cells is tightly regulated. B cells down-regulate the expression of functional CD154 in activated T cells through inhibition of CD154 mRNA expression and release of soluble CD40 that binds CD154.Synonyms: CD40 ligand, CD40-L, CD40LG, GP39, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TRAP, Tumor necrosis factor ligand superfamily member 5

ID gène: 959

NCBI Accession: NP_000065

UniProt: P29965

Pathways: Signalisation NF-kappaB, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints