CD55 anticorps

N° du produit ABIN1106464

Détail du produit anti-CD55 anticorps

Antigène: CD55 (Complement Decay-Accelerating Factor (CD55))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD55 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A agarose

Immunogène: Human adenocarcinoma cell line (PC3)

Clone: 2C6

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2. No preservative is contained.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD55

Antigène: CD55 (Complement Decay-Accelerating Factor (CD55))

Autre désignation: CD55 / DAF (CD55 Produits)

Synonymes: anticorps CR, anticorps CROM, anticorps DAF, anticorps TC, anticorps Daf, anticorps Daf-GPI, anticorps Daf1, anticorps GPI-DAF, anticorps CD55 molecule (Cromer blood group), anticorps CD55 molecule, decay accelerating factor for complement, anticorps CD55, anticorps Cd55

Sujet: CD55, also known as decay-accelerating factor (DAF), is a GPI-anchored membrane inhibitor of complement. It inhibits complement activation by interfering with the function of C3 and C5 convertases in both the classical and alternative pathways. CD55 is expressed on most cells to protect them from complement-mediated attack. CD55 and other membrane complement regulatory proteins (CD46 and CD59) are frequently overexpressed on cancer cells, possibly as a mechanism for cancer cells to overcome lysis by complement. Virus-receptor interactions have been elucidated for several viruses that use CD55 as an adhesion or invasion receptor, including enterovirus, echovirus, and coxsackie B virus. Moreover, CD55 also interacts with an epidermal growth factor-seven-span transmembrane (EGF-TM7) receptor, CD97. CD97 antigen becomes immediately up-regulated on most leukocytes during activation and is constitutively expressed by macrophages, dendritic cells, and some epithelial tumors.Synonyms: Complement decay-accelerating factor

ID gène: 9606

UniProt: P08174

Pathways: Système du Complément, Regulation of Leukocyte Mediated Immunity