CD55 anticorps (PE)
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- Antigène Voir toutes CD55 Anticorps
- CD55 (Complement Decay-Accelerating Factor (CD55))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp CD55 est conjugé à/à la PE
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Application
- Flow Cytometry (FACS), Immunofluorescence (IF)
- Specificité
- The antibody detects human CD55. Other species not tested. Cellular expression: platelets, monocytes, lymphocytes and erythrocytes.
- Purification
- Affinity chromatography
- Clone
- NaM16-4D3
- Isotype
- IgG1
- Top Product
- Discover our top product CD55 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Buffer
- 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.
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- Antigène
- CD55 (Complement Decay-Accelerating Factor (CD55))
- Autre désignation
- CD55 / DAF (CD55 Produits)
- Synonymes
- anticorps CR, anticorps CROM, anticorps DAF, anticorps TC, anticorps Daf, anticorps Daf-GPI, anticorps Daf1, anticorps GPI-DAF, anticorps CD55 molecule (Cromer blood group), anticorps CD55 molecule, decay accelerating factor for complement, anticorps CD55, anticorps Cd55
- Sujet
- CD55 is expressed as a 60-70 kD single chain Glycosylphosphatidylinositol (GPI) anchored glycoprotein (in erythrocytes). In other cells the molecular weight is somewhat larger. It is comprised of four N-terminal short consensus repeats (SCR) modules (4 Cys in 1-3,2-4 linkage) with C3b/C4b binding and regulator activity in SCR 2,3,4. CD55 is often involved in the protection of cells from autologous compliment-mediated injury and are partially or completely lacking in peripheral blood cells. CD55 inhibits the formation and accelerates the decay of C3/C5 convertase complexes both of classical and alternative pathway [1]. CD55 sets a protective barrier threshold against inappropriate complement activation and deposition on plasma membranes, especially by the classical pathway of complement activation, by limiting formation and half-life of the C3 convertases. Since CD55 is well known membrane-associated complement regulator protein, like CD59, and present on all blood cells, anti-CD55 and anti-CD59 appear to be the most effective Mabs to detect very minor negative cell subsets (less than 1 % on erythrocytes or less than 5 % on PMN leukocytes.Synonyms: Complement decay-accelerating factor
- ID gène
- 1604
- NCBI Accession
- NP_000565
- UniProt
- P08174
- Pathways
- Système du Complément, Regulation of Leukocyte Mediated Immunity
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