Dystroglycan anticorps

N° du produit ABIN1107039

Détail du produit anti-Dystroglycan anticorps

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Dystroglycan est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody is specific for a glycoepitope on brain bovine alpha-dystroglycan, which is absent on alpha-dystroglycan expressed in all other tissues.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat, rabbit, bovine

Purification: Protein G purified

Clone: 2238

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur Dystroglycan

Antigène: Dystroglycan (DAG1) (Dystroglycan 1 (DAG1))

Autre désignation: Dystroglycan (DAG1 Produits)

Synonymes: anticorps LOC398500, anticorps dag1, anticorps MGC53537, anticorps 156DAG, anticorps A3a, anticorps AGRNR, anticorps DAG, anticorps MDDGC7, anticorps MDDGC9, anticorps DAG1, anticorps RAB7, anticorps dg, anticorps a3a, anticorps dag, anticorps agrnr, anticorps 156dag, anticorps D9Wsu13e, anticorps DG, anticorps Dp427, anticorps Dp71, anticorps CG18250, anticorps CT41273, anticorps DmDG, anticorps Dmel\\CG18250, anticorps atu, anticorps dgn, anticorps dys, anticorps GB14967, anticorps APOJ, anticorps CLI, anticorps RATTRPM2B, anticorps SGP-2, anticorps SGP2, anticorps SP-40, anticorps SP40, anticorps TRPM-2, anticorps TRPM2B, anticorps Trpm2, anticorps Trpmb, anticorps Ala-1, anticorps H9/25, anticorps Ly-27, anticorps Ly-6, anticorps Ly27, anticorps wu:fb83d06, anticorps wu:fi25f06, anticorps wu:fi37b08, anticorps zgc:109786, anticorps DystroGlycaN, anticorps dystroglycan 1 L homeolog, anticorps dystroglycan 1, anticorps dystroglycan 1 S homeolog, anticorps Dystroglycan, anticorps dystroglycan, anticorps clusterin, anticorps lymphocyte antigen 6 complex, anticorps dgn-1, anticorps dag1.L, anticorps dgn-2, anticorps dgn-3, anticorps DAG1, anticorps dag1.S, anticorps Dag1, anticorps dag1, anticorps Dg, anticorps LOC408826, anticorps Clu, anticorps Ly6

Sujet: Alpha-dystroglycan (alpha-DG), also known as dystrophin-associated glycoprotein, is a laminin-binding protein of ~156 kDa (including glyco-groups). Alpha-DG is a component of the dystroglycan complex, which is involved in early development, morphogenesis and in the pathogenesis of muscular dystrophies. Alpha- and beta-DG are encoded by a single gene and are derived from a precursor polypeptide by posttranslational cleavage. Beta-DG is an integral membrane protein, whereas alpha-DG is membrane-associated through its noncovalent interaction with the extracellular domain of beta-DG. The alpha- and beta-DGs provide important physical linkages between components of basement membranes and cytoplasmic proteins that bind to the actin cytoskeleton. Alpha-DG is a heavily glycosylated, mucin-like protein anchored on the extracellular surface of the myotube, where it may provide linkage between the sarcolemma and extracellular matrix (ECM). Alpha-DG is expressed in a variety of fetal and adult tissues. Tissue-specific glycosylation modifies the laminin specificity of alpha-DG. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alpha-DG has been shown to colocalize with laminin in skeletal and cardiac muscle and a number of other cells including peripheral nerve, astrocytes, Purkinje neurons and kidney epithelium. Laminin-10/11 was shown to bind preferentially to brain alpha-DG. In Duchenne muscular dystrophy, the expression of alpha-DG is dramatically reduced leading to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. In the central nervous system, dystroglycan functions as a dual receptor for agrin and laminin-2 for instance in the Schwann cell membrane. Furthermore, defects in dystroglycan are central to the pathogenesis of structural and functional brain abnormalities seen in congenital muscular dystrophies (CMD).Synonyms: DAG1, Dystrophin-associated glycoprotein 1

ID gène: 281439

NCBI Accession: NP_776587

UniProt: O18738

Pathways: Maintenance of Protein Location, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus