HES1 anticorps (C-Term)

N° du produit ABIN1107521

L’anticorps Lapin Polyclonal anti-HES1 a été validé pour WB, IHC (fro) et EIA. Il convient pour détecter HES1 dans des échantillons de Souris.

Aperçu rapide pour HES1 anticorps (C-Term) (ABIN1107521)

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HES1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Détail du produit anti-HES1 anticorps

Épitope: C-Term

Specificité: Reacts with Mouse 30 kDa Hes1 protein. Cross reacts with Rat and Human.

Purification: Affinity Chromatography on Protein A

Immunogène: Synthetic peptide derived from C-terminal domain of HES-1 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in distilled water.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Détails sur HES1

Antigène: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Autre désignation: HES1

Sujet: HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.Synonyms: HES-1, HHL, HL, HRY, Hairy and enhancer of split 1, Hairy homolog, Hairy-like

ID gène: 15205

NCBI Accession: NP_032261

Pathways: Réparation de l'ADN