IFNA1 anticorps

N° du produit ABIN1107635

L’anticorps Rat Monoclonal anti-IFNA1 a été validé pour FACS, Func et EIA. Il convient pour détecter IFNA1 dans des échantillons de Souris.

Aperçu rapide pour IFNA1 anticorps (ABIN1107635)

Antigène: IFNA1 (Interferon, alpha 1 (IFNA1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp IFNA1 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: F18

Détail du produit anti-IFNA1 anticorps

Specificité: This antibody recognises most isoforms of natural and recombinant alpha Interferon. It does not cross-react with Murine beta or gamma Interferon, nor with Human alpha Interferon. The antibody exhibits neutralizing activity of approximately 6.25 x 10e4 neutralizing units/mg.

Réactivité croisée (Details): Species reactivity (tested):Mouse.

Purification: Protein G

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.

Date de péremption: 6 months

Détails sur IFNA1

Antigène: IFNA1 (Interferon, alpha 1 (IFNA1))

Autre désignation: IFNA1 / Interferon-alpha 1

Sujet: The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: IFN-alpha 1, IFNA13, Interferon alpha-D, LeIF D

ID gène: 15962

NCBI Accession: NP_034632

UniProt: P01572

Pathways: Signalistation JAK/STAT, Hepatitis C