IL-2 anticorps

N° du produit ABIN1107818

Détail du produit anti-IL-2 anticorps

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IL-2 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: The antibody detects human Interleukin 2, which is a 15 kDa molecular weight glycoprotein. Other species not tested.

Purification: Affinity chromatography

Clone: N7-48A

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: 0.01 M sodium phosphate, 0.15 M NaCl, pH 7.3, 0.2 % BSA, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. Fluorochrome labelled product is photosensitive and should be protected from light.

Détails sur IL-2

Antigène: IL-2 (IL2) (Interleukin 2 (IL2))

Autre désignation: Interleukin-2 / IL2 (IL2 Produits)

Synonymes: anticorps IL2, anticorps IL-2, anticorps il2, anticorps TCGF, anticorps lymphokine, anticorps Il-2, anticorps POIL2, anticorps interleukin 2, anticorps interleukin-15, anticorps IL2, anticorps il2, anticorps LOC100303688, anticorps Il2

Sujet: The immune system reacts to a pathogen by activation of balanced network of the humoral and cellular immune responses. Subsequently the activated condition of the immune system will, after the elimination of the pathogen, be down-regulated to a balanced situation again. Control of the immune response requires efficient communication between the different cells involved in this response. This interaction is provided by cell/cell contact and by a complex array of mediators. Among these mediators cytokines, soluble factors produced by these cells, play an important role. Cytokines can act on other cells locally or distantly, but can be even auto regulating. Cytokines can behave stimulatory or inhibitory, or can even perform both activities, depending on the (pre)activation stage of the target cell. (3, 4) Interleukine 2 (IL-2) is a cytokine expressed by human lymphocytes that have been stimulated by antigens or mitogens. Without stimulation, IL-2 is produced in low amounts by TH1 cells in vivo. Originally, IL-2 was referred to as T cell growth factor. T cell hybridomas or a leukemia cell line such as Jurkat, produce increased amounts of IL-2 in vitro. Stimulation with IL-2 leads to rapid clonal expansion of T cells and IL-2 acts on a variety of cells in vivo, such as B cells, NK cells, monocytes and macrophages. Furthermore, IL-2 can induce activation of LAK cells.Synonyms: IL-2, T-cell growth factor, TCGF

ID gène: 3558

NCBI Accession: NP_000577

UniProt: P60568

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation