LBP anticorps

N° du produit ABIN1108025

Détail du produit anti-LBP anticorps

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp LBP est non-conjugé

Application: Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Mouse

Purification: Protein G

Clone: M330-19

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur LBP

Antigène: LBP (Lipopolysaccharide Binding Protein (LBP))

Autre désignation: LBP (LBP Produits)

Synonymes: anticorps BPIFD2, anticorps Bpifd2, anticorps Ly88, anticorps LPSBP, anticorps LBP, anticorps lipopolysaccharide binding protein, anticorps lipopolysaccharide-binding protein, anticorps LBP, anticorps Lbp, anticorps LOC100472839

Sujet: LPS binding protein (LBP) is an approximately 60 kDa acute phase protein that is produced by hepatocytes. This protein strongly binds to LPS and has been shown to play an important role in the handling of LPS by the host. A number of functions of LBP have been reported. First, LBP transfers LPS to the LPS receptor CD14 on mononuclear phagocytes, leading to an 100-1,000-fold increased sensitivity of the cells to LPS. Furthermore, LBP can enhance the response of CD14 negative cells by acceleration of LPS binding to soluble CD14, a complex that stimulates these cells. Next, LBP transfers LPS into High Density Lipoprotein (HDL), which effectively neutralizes its biological potency. LBP was demonstrated to protect mice from septic shock caused by LPS or gram negative bacteria.Synonyms: Lipopolysaccharide-binding protein

ID gène: 10090

UniProt: Q61805

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Monocarboxylic Acid Catabolic Process