Ly6g anticorps

N° du produit ABIN1108437

Cet anticorps anti-Ly6g est un anticorps Rat Monoclonal détectant Ly6g dans FACS, IHC (fro), IHC (p), Func et EIA. Adapté pour Souris. Ce Primary Antibody a été cité dans 9+ publications.

Aperçu rapide pour Ly6g anticorps (ABIN1108437)

Antigène: Ly6g (Lymphocyte Antigen 6 Complex, Locus G (Ly6g))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Ly6g est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: NIMP-R14

Détail du produit anti-Ly6g anticorps

Réactivité croisée (Details): Species reactivity (tested):Mouse.

Purification: Protein G Chromatography

Immunogène: Purified BALB/c Mouse Neutrophils

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Stock: 4 °C

Stockage commentaire: Store undiluted at 2-8 °C.

Références pour anticorps anti-Ly6g (ABIN1108437)

Navarini, Lang, Verschoor, Recher, Zinkernagel, Nizet, Odermatt, Hengartner, Zinkernagel: "Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 17, pp. 7107-12, (2009) (PubMed).

Nagendra, Schlueter: "Absence of cross-reactivity between murine Ly-6C and Ly-6G." dans: Cytometry. Part A : the journal of the International Society for Analytical Cytology, Vol. 58, Issue 2, pp. 195-200, (2004) (PubMed).

de Vries, Köhl, Leclercq, Wolfs, van Bijnen, Heeringa, Buurman: "Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 7, pp. 3883-9, (2003) (PubMed).

Tacchini-Cottier, Zweifel, Belkaid, Mukankundiye, Vasei, Launois, Milon, Louis: "An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania major." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 5, pp. 2628-36, (2000) (PubMed).

Lubberts, Joosten, van Den Bersselaar, Helsen, Bakker, van Meurs, Graham, Richards, van Den Berg: "Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4546-56, (1999) (PubMed).

Van Lent, Blom, Holthuysen, Jacobs, Van De Putte, Van Den Berg: "Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice." dans: Journal of leukocyte biology, Vol. 61, Issue 3, pp. 267-78, (1997) (PubMed).

Fabrizi, Rizzuto, Nakase, Mita, Lomax, Grossman, Schon: "Sequence of a cDNA specifying subunit VIIa of human cytochrome c oxidase." dans: Nucleic acids research, Vol. 17, Issue 17, pp. 7107, (1989) (PubMed).

McLaren, Strath, Smithers: "Schistosoma mansoni: evidence that immunity in vaccinated and chronically infected CBA/Ca mice is sensitive to treatment with a monoclonal antibody that depletes cutaneous effector cells." dans: Parasite immunology, Vol. 9, Issue 6, pp. 667-82, (1988) (PubMed).

Lopez, Strath, Sanderson: "Differentiation antigens on mouse eosinophils and neutrophils identified by monoclonal antibodies." dans: British journal of haematology, Vol. 57, Issue 3, pp. 489-94, (1984) (PubMed).

Détails sur Ly6g

Antigène: Ly6g (Lymphocyte Antigen 6 Complex, Locus G (Ly6g))

Autre désignation: Ly6G / GR1 Neutrophil Marker

Sujet: The Ly-6G/-6C locus encodes a family of Ly-6 proteins including Ly-6G and Ly-6C. Ly-6 antigens have a molecular weight between 15,000 and 18,000. Ly6G is together with Ly6c a component of the myeloid differentiation antigen Gr-1. Ly6G a GPI-anchored protein and is a good marker of peripheral neutrophils. Although predominantly presents on neutrophils, it is also expressed on a subset of eosinophils, differentiating pre-monocytes and plasmacytoid dendritic cells. Ly6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon gamma, and may play a role in the development and maturation of lymphocytes. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T cell subsets. Expression of Gr-1 in bone marrow correlates with granulocyte differentiation and maturation. However, the physiological role of Ly6G alone remains still unclear.Synonyms: Gr-1 Granulocyte marker

ID gène: 10090

UniProt: P35461