Retinoblastoma 1 anticorps (AA 612-928)

N° du produit ABIN1108868

L’anticorps anti-Retinoblastoma 1 Monoclonal Souris est utilisé pour la détection de Retinoblastoma 1 dans des échantillons de Humain. Il a été validé pour WB, IP et IHC (p).

Aperçu rapide pour Retinoblastoma 1 anticorps (AA 612-928) (ABIN1108868)

Antigène: Retinoblastoma 1 (RB1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3H9

Détail du produit anti-Retinoblastoma 1 anticorps

Épitope: AA 612-928

Specificité: This antibody reacts with retinoblastoma gene product (110-115 kDa).

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein A Sepharose

Immunogène: Recombinant human Rb protein corresponding to amino acids 612-928

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur Retinoblastoma 1

Antigène: Retinoblastoma 1 (RB1)

Autre désignation: Retinoblastoma-Associated Protein / RB1

Sujet: Mutation of the retinoblastoma tumor suppressor gene alone is sufficient to cause retinoblastoma in humans, suggesting that it might play a role in the normal coordination of cell proliferation and cell death. Deletion or mutational inactivation of the retinoblastoma tumor suppressor protein (Rb) is correlated with the genesis of a variety of human cancers including retinoblastoma, osteosarcoma, and carcinomas of the breast, bladder, and lung. Rb protein is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of Rb. Rb undergoes phosphorylation and functional inactivation, permitting the cell to proceed into late G1.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

ID gène: 5925

NCBI Accession: NP_000312

UniProt: P06400

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy