S100A12 anticorps

N° du produit ABIN1108920

Cet anticorps anti-S100A12 Monoclonal Souris (Clone 19F5) (ABIN1108920) détecte spécifiquement S100A12 dans WB, EIA et IHC (fro). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour S100A12 anticorps (ABIN1108920)

Antigène: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp S100A12 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 19F5

Détail du produit anti-S100A12 anticorps

Specificité: Reacts with 10 kDa Human S100A12 protein. No cross reaction with the other S100 protein family.

Purification: Affinity Chromatography on Protein A

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in distilled water.

Buffer: PBS, None

Détails sur S100A12

Antigène: S100A12 (S100 Calcium Binding Protein A12 (S100A12))

Autre désignation: S100A12

Sujet: S100 family proteins are acidic low molecular weight proteins containing 2 EF-hand calcium binding domains. They are characterised by their cell-type specific expression patterns. S100A12 is a member of the calgranulin sub-family. Calgranulins are S100 proteins that are expressed by neutrophils and also found in infiltrating monocytes and granulocytes during chronic inflammation. S100A12 is expressed in neutrophils and monocytes. It is highly abundant in resting neutrophils, comprising 5 % of total cytostolic protein. S100A12 is a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.Synonyms: CAAF1, CAGC, CGRP, Calcium-binding protein in amniotic fluid 1, Calgranulin-C, EN-RAGE, Extracellular newly identified RAGE-binding protein, Neutrophil S100 protein, S100 calcium-binding protein A12, S100-A12

ID gène: 6283

Pathways: Toll-Like Receptors Cascades, S100 Proteins