TREM1 anticorps

N° du produit ABIN1109324

L’anticorps anti-TREM1 Monoclonal Souris est utilisé pour la détection de TREM1 dans des échantillons de Humain. Il a été validé pour WB, Func et EIA.

Aperçu rapide pour TREM1 anticorps (ABIN1109324)

Antigène: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TREM1 est non-conjugé

Application: Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: 6B1

Détail du produit anti-TREM1 anticorps

Specificité: This antibody recognizes human triggering receptor expressed on myeloid cells 1 (TREM-1). It recognizes both membrane bound and soluble TREM-1. Also, the antibody neutralizes the interaction between TREM-1 and its ligand.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein G

Immunogène: Recombinant TREM-1 - IgG1 fusion protein

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Stock: 4 °C

Stockage commentaire: Store at 2 - 8 °C.

Détails sur TREM1

Antigène: TREM1 (Triggering Receptor Expressed On Myeloid Cells 1 (TREM1))

Autre désignation: TREM1

Sujet: TREM-1 is a transmembrane glycoprotein belonging to a family related to the natural killer cell receptors. TREM-1 is an important activating receptor, of 26 kDa, involved in the innate inflammatory response and in sepsis. TREM-1 is expressed at low levels in the early development of the hematopoietic system and in the promonoistic stage and at high levels on neutrophil granulocytes (PMN), monocytes, and macrophage subsets. The expression of TREM-1 is upregulated by microbial products, that is, by toll-like receptor ligands such as lipoteichoic acid (LTA) of Gram-positive or lipopolysaccharide (LPS) of Gram-negative bacteria. Ligation of TREM-1 is synergistic with TLR agonists on the activation of receptor bearing cells. Platelets express a natural ligand for TREM-1. Receptor ligation activates the full repertoire of effector functions. TREM-1 is also produced in a soluble form (sTREM-1) of 17 kDa which is released in humans after endotoxin exposition or in patients suffering from severe pneumonia or sepsis. sTREM-1 can be measured in biological fluids and may be useful as a diagnostic tool.Synonyms: Triggering receptor expressed on monocytes 1, Triggering receptor expressed on myeloid cells 1

ID gène: 54210

NCBI Accession: NP_061113

UniProt: Q9NP99