CHMP3 anticorps

N° du produit ABIN1109497

Cet anticorps Lapin Polyclonal détecte spécifiquement CHMP3 dans WB, IF et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CHMP3 anticorps (ABIN1109497)

Antigène: CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CHMP3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Détail du produit anti-CHMP3 anticorps

Specificité: Reacts with 25 kDa hVps24.

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography on Protein A

Immunogène: Synthetic peptide derived from internal domain of Human Vps24 protein

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CHMP3

Antigène: CHMP3 (Charged Multivesicular Body Protein 3 (CHMP3))

Autre désignation: VPS24

Sujet: The charged multivesicular body proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP3, also known as Vps24, associates directly with CHMP2 and CHMP4 for the disassembly of ESCRT-III complex in an ATP-dependent manner. During HIV-1 infection, the virus uses the ESCRT-III complex to mediate budding and exocytosis of viral proteins. Overexpression of CHMP3 strongly inhibits HIV-1 release. CHMP3 is expressed in brain, skeletal muscle, heart, lung, kidney and liver.Synonyms: CGI-149, CHMP3, Charged multivesicular body protein 3, Chromatin-modifying protein 3, NEDF, Neuroendocrine differentiation factor, Vacuolar protein-sorting-associated protein 24

ID gène: 51652

NCBI Accession: NP_001005753