APOA1 anticorps

N° du produit ABIN111087

Cet anticorps anti-APOA1 Monoclonal Souris (Clone 1404) (ABIN111087) détecte spécifiquement APOA1 dans RIA et EIA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour APOA1 anticorps (ABIN111087)

Antigène: APOA1 (Apolipoprotein A-I (APOA1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp APOA1 est non-conjugé

Application: Radioimmunoassay (RIA), Enzyme Immunoassay (EIA)

Clone: 1404

Détail du produit anti-APOA1 anticorps

Specificité: Hihgly specific for APO A-I, no cross reactivity with APO A-II or Apo B.Aff. Const.:8 x 10e9

Purification: DEAE-chromatography

Immunogène: Purified human plasma Apo A-I

Isotype: IgG1

Information d'application

Indications d'application: Competeitive RIA. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 3.84 mg/mL (OD280 nm, E1% = 14)

Buffer: 0.015 M PBS, 0.15 M NaCl, pH 7.2 with 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur APOA1

Antigène: APOA1 (Apolipoprotein A-I (APOA1))

Autre désignation: Apolipoprotein A I (APO AI)

Sujet: Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids, an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.Synonyms: APOA1, Apo-AI, ApoA-I, ApoAI

ID gène: 335

NCBI Accession: NP_000030

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism