Cardiotrophin 1 anticorps

N° du produit ABIN1110877

Détail du produit anti-Cardiotrophin 1 anticorps

Antigène: Cardiotrophin 1 (CTF1)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cardiotrophin 1 est non-conjugé

Application: ELISA

Fonction: Mouse Anti-Human CT1

Attributs du produit: Cardiac Markers

Purification: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen.PurificationThe IgG fraction of tissue culture supernatant was purified by Protein A/G affinity chromatography.

Isotype: IgG

Information d'application

Indications d'application: ELISA

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: The antibody is supplied as lyophilized and purified antibody originally containing PBS without any preservatives. Protein amount is indicated on the vial. Reconstitute in de-ionized or distilled water to concentration of 1 mg/mL.

Buffer: PBS

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: -20°C

Références pour anticorps anti-Cardiotrophin 1 (ABIN1110877)

Li, Ma, Wang, Zeng, Li, Kang, Hao: "Exosomal microRNA-141 is upregulated in the serum of prostate cancer patients." dans: OncoTargets and therapy, Vol. 9, pp. 139-48, (2016) (PubMed).

Détails sur Cardiotrophin 1

Antigène: Cardiotrophin 1 (CTF1)

Autre désignation: CT1 (CTF1 Produits)

Synonymes: anticorps CTF1, anticorps ct1, anticorps ct-1, anticorps ctf2, anticorps CT-1, anticorps CT1, anticorps cardiotrophin 1, anticorps cardiotrophin-1, anticorps CTF1, anticorps ctf1, anticorps Ctf1, anticorps LOC100736818

Sujet:

Target Description: Cardiotrophin-1 (CT-1, Official gene name: CTF1) is a cardiac hypertrophic factor and belongs to the IL-6 cytokine family. The protein interacts with the glycoprotein 130/leukemia inhibitory factor receptor beta heterodimer. CT-1 deficiency causes increased motoneuron cell death in spinal cord and brainstem nuclei of mice. In addition, CT-1 enhances transcription factor NF kappa B DNA-binding activities and activates phosphatidylinositol 3-kinase in cardiac myocytes. It is also highly expressed in the heart, prostate, skeletal muscle, and ovary, and expressed at the lower levels in lung, kidney, pancreas, thymus, small intestine, and testis. CT-1 is highly secreted by myotubes, and promotes the survival of cultured embryonic mouse and rat MNs. CT-1 is associated with pathophysiology of heart diseases, like hypertension, myocardial infarction, valvular heart disease, and congestive heart failure.

Pathways: Signalistation JAK/STAT