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Cytokeratin 18 anticorps (FITC)

KRT18 Reactivité: Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Hamster, Mouton, Truite IF, FACS, IHC (p), IHC (fro) Hôte: Souris Monoclonal Ks18-04 FITC
N° du produit ABIN111182
  • Antigène Voir toutes Cytokeratin 18 (KRT18) Anticorps
    Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))
    Reactivité
    • 255
    • 151
    • 112
    • 44
    • 35
    • 28
    • 25
    • 21
    • 19
    • 18
    • 17
    • 14
    • 14
    • 14
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Hamster, Mouton, Truite
    Hôte
    • 165
    • 125
    • 3
    • 1
    • 1
    Souris
    Clonalité
    • 151
    • 144
    Monoclonal
    Conjugué
    • 145
    • 26
    • 22
    • 11
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Cet anticorp Cytokeratin 18 est conjugé à/à la FITC
    Application
    • 217
    • 100
    • 84
    • 80
    • 74
    • 60
    • 54
    • 40
    • 39
    • 27
    • 26
    • 19
    • 8
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificité
    Ks 18.04 represents an excellent marker to discriminate simple epithelia from those of different origin. Tumors Specifically Detected: all adenocarcinoma, mammary carcinoma, urinary bladder carcinoma, undifferentiated carcinoma, cervix carcinoma, hepatocellular carcinoma. Polypeptide Reacting: Mr 45 000 polypeptide (human keratin K18) of all simple type epithelia and basal cells of many squamous, nonepidermal epithelia. Reacts with HeLa and MCF-7 (cell lines tested so far).
    Purification
    Protein A Chromatography
    Immunogène
    Human keratin K18 from a HeLa cytoskeletal preparation
    Clone
    Ks18-04
    Isotype
    IgG1
    Top Product
    Discover our top product KRT18 Anticorps primaire
  • Indications d'application
    Immunoflourescence. Cytological material. Flow Cytometry: 1/5-1/10. Immunohistochemistry of Frozen Sections. Immunohistochemistry of Paraffin Sections: 1/10. Working dilution: 1/10 for immunohistochemistry. Incubation Time: 1 h at 37 °C.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Trowe, Airik, Weiss, Farin, Foik, Bettenhausen, Schuster-Gossler, Taketo, Kispert: "Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter." dans: Development (Cambridge, England), Vol. 139, Issue 17, pp. 3099-108, (2012) (PubMed).

    Hantel, Lewrick, Schneider, Zwermann, Perren, Reincke, Süss, Beuschlein: "Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency." dans: The Journal of clinical endocrinology and metabolism, Vol. 95, Issue 2, pp. 943-52, (2010) (PubMed).

    Sharma, Cantz, Richter, Eckert, Henschler, Wilkens, Jochheim-Richter, Arseniev, Ott: "Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver." dans: The American journal of pathology, Vol. 167, Issue 2, pp. 555-64, (2005) (PubMed).

    Ikenouchi, Matsuda, Furuse, Tsukita: "Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail." dans: Journal of cell science, Vol. 116, Issue Pt 10, pp. 1959-67, (2003) (PubMed).

    Stumptner, Fuchsbichler, Heid, Zatloukal, Denk: "Mallory body--a disease-associated type of sequestosome." dans: Hepatology (Baltimore, Md.), Vol. 35, Issue 5, pp. 1053-62, (2002) (PubMed).

    Bantel, Ruck, Gregor, Schulze-Osthoff: "Detection of elevated caspase activation and early apoptosis in liver diseases." dans: European journal of cell biology, Vol. 80, Issue 3, pp. 230-9, (2001) (PubMed).

    Gomi, Yokoyama, Fujimoto, Ikeda, Katoh, Itoh, Itohara: "Mice devoid of the glial fibrillary acidic protein develop normally and are susceptible to scrapie prions." dans: Neuron, Vol. 14, Issue 1, pp. 29-41, (1995) (PubMed).

    Bártek, Vojt?sek, Stasková, Bártková, Kerekés, Rejthar, Kovarík: "A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology." dans: The Journal of pathology, Vol. 164, Issue 3, pp. 215-24, (1991) (PubMed).

    Lauerová, Kovarik, Bártek, Rejthar, Vojt?sek: "Novel monoclonal antibodies defining epitope of human cytokeratin 18 molecule." dans: Hybridoma, Vol. 7, Issue 5, pp. 495-504, (1989) (PubMed).

    Moll, Franke, Schiller, Geiger, Krepler: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." dans: Cell, Vol. 31, Issue 1, pp. 11-24, (1983) (PubMed).

  • Antigène
    Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))
    Autre désignation
    Cytokeratin 18 (KRT18 Produits)
    Synonymes
    anticorps CK18, anticorps K18, anticorps Krt1-18, anticorps CYK18, anticorps DreK18, anticorps cb83, anticorps dapk1, anticorps sb:cb83, anticorps wu:fa13f02, anticorps wu:fb36b04, anticorps krt18, anticorps MGC64569, anticorps MGC75922, anticorps KRT18, anticorps CK-18-A, anticorps K18-A, anticorps NC-11, anticorps cyk18, anticorps k18, anticorps krt18-a, anticorps krt18-b, anticorps krt18a, anticorps xkendob, anticorps keratin 18, anticorps keratin 18, type I L homeolog, anticorps keratin 18, type I, anticorps keratin, type I cytoskeletal 18, anticorps K18, simple type I keratin, anticorps Keratin, type I cytoskeletal 18, anticorps keratin 18, type I S homeolog, anticorps Krt18, anticorps KRT18, anticorps krt18, anticorps krt18.L, anticorps LOC700569, anticorps LOC100136778, anticorps k1c18, anticorps LOC100008885, anticorps krt18.S
    Sujet
    Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.Synonyms: CK18, CYK18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, K18, KRT18, Keratin 18, Keratin type I cytoskeletal 18, Keratin-18
    ID gène
    3875
    NCBI Accession
    NP_000215
    UniProt
    P05783
    Pathways
    Apoptose, Caspase Cascade in Apoptosis
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