KLKB1 anticorps

N° du produit ABIN111208

Cet anticorps Souris Monoclonal détecte spécifiquement KLKB1 dans WB, EIA et Func. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour KLKB1 anticorps (ABIN111208)

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KLKB1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)

Clone: 901

Détail du produit anti-KLKB1 anticorps

Specificité: Recognizes two variants of Prekallikrein and its activation products Kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and Antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). Recognizes Prekallikrein and its activation products in Human, Chimpanzee, Rhesus, and Baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in Human and Rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue Kallikrein

Purification: Protein G chromatography.

Immunogène: Purified Human prekallikrein.

Isotype: IgG1

Information d'application

Indications d'application: Suitable for use in ELISA and Western blot. Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasmasamples.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.6 mg/mL (OD280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur KLKB1

Antigène: KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))

Sujet: Plasma Kallikrein 1B is a serine proteinase of the S1 family It is secreted by the liver, kidney, adrenal gland and placenta. The zymogen is referred to as prekallikrein (PK) and is activated by Factor XIIa to an active two chain form, plasma kallikrein. In Fletcher syndrome plasma kallikrein is deficient, resulting in a prolonged partial thromboplastin time (PT).Synonyms: Fletcher factor, Plasma kallikrein

ID gène: 3818

NCBI Accession: NP_000883

UniProt: P03952

Pathways: Système du Complément, Brown Fat Cell Differentiation