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S100A8 anticorps (C-Term) (Biotin)

S100A8 Reactivité: Humain, Rat, Porc WB, FACS, IHC (p), IHC (fro), EIA Hôte: Souris Monoclonal S13-67 Biotin
N° du produit ABIN111893
  • Antigène Voir toutes S100A8 Anticorps
    S100A8 (S100 Calcium Binding Protein A8 (S100A8))
    Épitope
    • 18
    • 18
    • 16
    • 9
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 84
    • 51
    • 32
    • 14
    • 9
    • 7
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    Humain, Rat, Porc
    Hôte
    • 81
    • 37
    • 3
    • 3
    • 1
    • 1
    Souris
    Clonalité
    • 86
    • 40
    Monoclonal
    Conjugué
    • 65
    • 20
    • 16
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp S100A8 est conjugé à/à la Biotin
    Application
    • 74
    • 47
    • 43
    • 30
    • 16
    • 15
    • 14
    • 14
    • 13
    • 12
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificité
    S 13.67 identifies the Ca2+-binding light subunit of the inflammatory L-1 protein complex, also called S100A8 or Calgranulin A. S 13.67 is useful for the identification of the 8 kDa S100A8 subunit in various immunological techniques. Histological and serological data indicate that MRP8 is associated with chronic stages of inflammatory diseases. S13.67 detects a very distinct, as yet not characterized epitope of MRP8 (different from the 8-5C2 epitope). Antigen Distribution Isolated cells: The antigen is found in granulocytes and monocytes. It is absent from other blood cells. In cultured monocytes, maximum MRP8 is expressed after 3-4 days. Myeloid leukaemia stains positively. Tissue Sections: In the tissue, MRP-8 is only found in a distinct subpopulation of inflammatory perivascular infiltrates of the myelo-monocytic lineage. Macrophages synthesise MRP-8 increasingly during the late stages of inflammation. A low MRP-8 (and high MRP-14) expression by macrophages was also reported in granulomatous diseases such as tuberculosis and sarcoidis. In non-granulomatous chronic inflammatory diseases such as chronic rheumatoid arthritis MRP8 and MRP14 positive cells consist of different subpopulations. During early inflammation endothelial cells are also positive with MRP8 / MRP14(TNF-alpha/IL-1 alpha induced inflammation of the skin).
    Réactivité croisée (Details)
    Species reactivity (tested):Human: MRP8 in stimulated monocytes and macrophages inlate phase or chronic inflammation.Rat, Cow, Pig (TNF-alpha/IL-1 alpha induced inflammation of the skin).
    Purification
    Affinity Chromatography
    Immunogène
    Cultured Human Monocytes. Remarks: The antigen is MRP8, the epitope is suspected in the N- or C-terminal portion of the peptide.
    Clone
    S13-67
    Isotype
    IgG1
    Top Product
    Discover our top product S100A8 Anticorps primaire
  • Indications d'application
    Flow cytometry. Immunohistochemistry on: Frozen sections: 1 μg/mL (1: 200)Paraffin sections: 5-10 μg/mL (1: 20-1: 50), no pretreatment for antigen retrieval necessary.
    Restrictions
    For Research Use only
  • Reconstitution
    Restore in 0.5 mL distilled water to make stock solution.
    Concentration
    0.2 mg/mL
    Buffer
    PBS, pH 7.2 with 10 mg/mL BSA as a stabilizer and 0.01 % Thimerosal as a preservative
    Agent conservateur
    Thimerosal (Merthiolate)
    Précaution d'utilisation
    This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    This product is photosensitive and should be protected from light
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
  • Antigène
    S100A8 (S100 Calcium Binding Protein A8 (S100A8))
    Autre désignation
    S100A8 / Calgranulin-A / MRP8 (S100A8 Produits)
    Synonymes
    anticorps 60B8AG, anticorps CAGA, anticorps CFAG, anticorps CGLA, anticorps CP-10, anticorps L1Ag, anticorps MA387, anticorps MIF, anticorps MRP8, anticorps NIF, anticorps P8, anticorps Mrp8, anticorps S100A8, anticorps 60B8Ag, anticorps AI323541, anticorps B8Ag, anticorps CFAg, anticorps Caga, anticorps p8, anticorps MRP-8, anticorps S100 calcium binding protein A8, anticorps S100 calcium binding protein A8 (calgranulin A), anticorps S100A8, anticorps S100a8
    Sujet
    MRP8 is the Ca2+-binding light subunit of Calprotectin. MRP8 forms Ca2+-dependent or complexes with MRP14 (S100A9, Calgranulin B). It also forms disulfide-linked homodimers under the influence of hypochlorite, a process thought to abrogate the chemotactic property of MRP8.Synonyms: CAGA, CFAG, Calprotectin L1L subunit, Cystic fibrosis antigen, Leukocyte L1 complex light chain, MRP-8, Migration inhibitory factor-related protein 8, S100 calcium-binding protein A8, S100-A8, Urinary stone protein band A
    ID gène
    9606
    UniProt
    P05109
    Pathways
    Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins
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