Chromogranin A anticorps (C-Term)

N° du produit ABIN115295

L’anticorps anti-Chromogranin A Polyclonal Lapin est utilisé pour la détection de Chromogranin A dans des échantillons de Humain. Il a été validé pour IHC (p) et IHC (fro).

Aperçu rapide pour Chromogranin A anticorps (C-Term) (ABIN115295)

Antigène: Chromogranin A (CHGA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Chromogranin A est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-Chromogranin A anticorps

Épitope: C-Term

Specificité: This antibody reacts with human Chromogranin A in the neuroendocrine cells and neural tissues. It does not recognizes the epitopes located on the N-terminal half of the chromogranin A molecule.
Cellular Localization: Cytoplasmic.

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Purified

Immunogène: C-terminal half of chromogranin A was purified from urine of patients with carcinoid syndrome.

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Embedded Sections: 1/20-1/50 in an ABC method(30-60 minutes at room temperature)Recommended Positive Control: Pancreas.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM Citrate buffer, pH 6.0 containing Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Chromogranin A

Antigène: Chromogranin A (CHGA)

Autre désignation: Chromogranin A

Sujet: Chromogranin A (a protein of 439 amino acids which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.Synonyms: CHGA, CgA, Chromogranin-A, Pituitary secretory protein I, SP-I

ID gène: 1113

NCBI Accession: NP_001266

UniProt: P10645

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling