FABP4 anticorps (N-Term)

N° du produit ABIN115503

Cet anticorps anti-FABP4 est un anticorps Lapin Polyclonal détectant FABP4 dans WB et IHC (fro). Adapté pour Humain.

Aperçu rapide pour FABP4 anticorps (N-Term) (ABIN115503)

Antigène: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FABP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-FABP4 anticorps

Épitope: N-Term

Séquence: MCDAFVGTWK LVSSENFDDY MKEVGVGFAT RKVAGMAKPN MIISVNGDVI TIKSESTFKN TEISFILGQE FDEVTADDRK VKSTITLDGG VLVHVQKWDG KSTTIKRKRE DDKLVVECVM KGVTSTRVYE RA

Specificité: This antibody recognizes Adipocyte Fatty Acid Binding Protein (FABP4/AFABP).

Réactivité croisée (Details): Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogène: The immunization antigen (14.7 kDa) is a protein containing 131 AA of recombinant Human FABP4 and one extra AA, N-terminal Methionin (highlighted).

Information d'application

Indications d'application: Western Blot. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 0.05 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.

Buffer: 0.05 M Phosphate buffer, 0.1 M NaCl, pH 7.2 without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.

Date de péremption: 6 months

Détails sur FABP4

Antigène: FABP4 (Fatty Acid Binding Protein 4, Adipocyte (FABP4))

Autre désignation: FABP4

Sujet: Adipocyte fatty acid binding protein AFABP is a 15 kDa member of the intracellular fatty acid binding protein (FABP) family, which is known for the ability to bind fatty acids and related compounds (bile acids or retinoids) in an internal cavity. AFABP is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells . In mice, targeted mutations in AFABP provide significant protection from hyperinsulinemia and insulin resistance in the context of both dietary and genetic obesity. Adipocytes obtained from AFABP-deficient mice also have reduced fficiency of lipolysis in vitro and in vivo, and these mice exhibited moderately improved systemic dyslipidemia. Recent studies also demonstrated AFABP expression in macrophages upon differentiation and activation. In these cells, AFABP modulates inflammatory responses and cholesterol ester accumulation, and total or macrophage-specific AFABP deficiency confers dramatic protection against atherosclerosis in the apoE-/- mice. These results indicate a central role for AFABP in the development of major components of the metabolic syndrome through its distinct actions in adipocytes and macrophages.Synonyms: A-FABP, Adipocyte lipid-binding protein, Fatty acid-binding protein 4

ID gène: 2167

NCBI Accession: NP_001433

UniProt: P15090

Pathways: Brown Fat Cell Differentiation