NOTCH2 anticorps

N° du produit ABIN1169006

Détail du produit anti-NOTCH2 anticorps

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Reactivité: Humain, Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp NOTCH2 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Recognizes human and mouse endogenous Notch-2 receptor.

Réactivité croisée: Humain, Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse Notch2:Fc .

Clone: 16F11

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-NOTCH2 (ABIN1169006)

Ribeiro, Hasan, Wilson, Boucontet, Pereira, Lesjean-Pottier, Satoh-Takayama, Di Santo, Vosshenrich: "Cutting edge: Thymic NK cells develop independently from T cell precursors." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 9, pp. 4993-7, (2010) (PubMed).

Fiorini, Merck, Wilson, Ferrero, Jiang, Koch, Auderset, Laurenti, Tacchini-Cottier, Pierres, Radtke, Luther, Macdonald: "Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7212-22, (2009) (PubMed).

Détails sur NOTCH2

Antigène: NOTCH2 (Notch 2 (NOTCH2))

Autre désignation: Notch2 (NOTCH2 Produits)

Synonymes: anticorps AGS2, anticorps HJCYS, anticorps hN2, anticorps AI853703, anticorps N2, anticorps notch6, anticorps sb:cb884, anticorps neurogenic locus notch homolog protein 2, anticorps notch 2, anticorps notch 3, anticorps LOC581186, anticorps NOTCH2, anticorps notch3, anticorps Notch2, anticorps notch2

Sujet: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.

UniProt: O35516

Pathways: Signalisation Notch, Stem Cell Maintenance