SIRT6 anticorps

N° du produit ABIN1169069

L’anticorps anti-SIRT6 Monoclonal produit chez le Souris a été validé pour WB et ELISA. Il convient pour la détection de SIRT6 dans des échantillons provenant de Humain. }

Aperçu rapide pour SIRT6 anticorps (ABIN1169069)

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SIRT6 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: S6R82-2

Détail du produit anti-SIRT6 anticorps

Specificité: Recognizes human sirtuin 6. Detects a band of ~47 kDa by Western blot.

Réactivité croisée: Humain

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human sirtuin 6.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur SIRT6

Antigène: SIRT6 (Sirtuin 6 (SIRT6))

Autre désignation: Sirtuin 6

Sujet: Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

UniProt: Q8N6T7