ZBP1 anticorps (AA 1-411)

N° du produit ABIN1169142

Cité dans 3 publications. Cet anticorps anti-ZBP1 Monoclonal Souris (Clone Zippy-1) (ABIN1169142) détecte spécifiquement ZBP1 dans WB, IP et ICC. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour ZBP1 anticorps (AA 1-411) (ABIN1169142)

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ZBP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone: Zippy-1

Détail du produit anti-ZBP1 anticorps

Épitope: AA 1-411

Fonction: anti-ZBP1, mAb (Zippy-1)

Specificité: Recognizes human and mouse ZBP1.

Attributs du produit: Monoclonal Antibody. Recognizes human and mouse ZBP1. Isotype: Mouse IgG2a. Clone: Zippy-1. Applications: ICC, IP, WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse ZBP1 (aa 1-411).

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-ZBP1 (ABIN1169142)

Christgen, Zheng, Kesavardhana, Karki, Malireddi, Banoth, Place, Briard, Sharma, Tuladhar, Samir, Burton, Kanneganti: "Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)." dans: Frontiers in cellular and infection microbiology, Vol. 10, pp. 237, (2020) (PubMed).

Kuriakose, Zheng, Neale, Kanneganti: "IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 4, pp. 1489-1495, (2019) (PubMed).

Kesavardhana, Kuriakose, Guy, Samir, Malireddi, Mishra, Kanneganti: "ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death." dans: The Journal of experimental medicine, Vol. 214, Issue 8, pp. 2217-2229, (2017) (PubMed).

Détails sur ZBP1

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Autre désignation: ZBP1

Sujet:

Alternate Names/Synonyms: Z-DNA-binding Protein 1, Tumor Stroma and Activated Macrophage Protein DLM-1, DNA-dependent Activator of IFN-regulatory Factors, DAI

Product Description: ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection.

UniProt: Q9H171