ZBP1 anticorps (AA 1-411)

N° du produit ABIN1169142

Détail du produit anti-ZBP1 anticorps

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Épitope: AA 1-411

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ZBP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Specificité: Recognizes human and mouse ZBP1.

Réactivité croisée: Humain, Souris

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Recombinant mouse ZBP1 (aa 1-411)

Clone: Zippy-1

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-ZBP1 (ABIN1169142)

Christgen, Zheng, Kesavardhana, Karki, Malireddi, Banoth, Place, Briard, Sharma, Tuladhar, Samir, Burton, Kanneganti: "Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis)." dans: Frontiers in cellular and infection microbiology, Vol. 10, pp. 237, (2020) (PubMed).

Kuriakose, Zheng, Neale, Kanneganti: "IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 4, pp. 1489-1495, (2019) (PubMed).

Kesavardhana, Kuriakose, Guy, Samir, Malireddi, Mishra, Kanneganti: "ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death." dans: The Journal of experimental medicine, Vol. 214, Issue 8, pp. 2217-2229, (2017) (PubMed).

Détails sur ZBP1

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Autre désignation: ZBP1 (ZBP1 Produits)

Synonymes: anticorps C20orf183, anticorps DAI, anticorps DLM-1, anticorps DLM1, anticorps 2010010H03Rik, anticorps Dai, anticorps Dlm1, anticorps mZaDLM, anticorps ZBP1, anticorps Z-DNA binding protein 1, anticorps ZBP1, anticorps Zbp1

Sujet: ZBP1 is an interferon inducible protein that binds to cytoplasmic DNA and plays a role in host defense against tumors and pathogens. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. ZBP1 is an innate immune sensor of Influenza A virus (IAV). ZBP1 regulates NLRP3 (nucleotide and oligomerization domain, leucine-rich repeat-containing protein family, pyrin domain containing 3) inflammasome activation as well as induction of different types of cell death (apoptosis, necroptosis and pyroptosis) during IAV infection.

UniProt: Q9H171