ZBP1 anticorps (C-Term)

N° du produit ABIN6990827

Détail du produit anti-ZBP1 anticorps

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZBP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificité: Multiple isoforms of ZBP1 are known to exist.

Purification: ZBP1 Antibody is affinity chromatography purified via peptide column.

Immunogène: ZBP1 antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. The immunogen is located within the last 50 amino acids of ZBP1.

Isotype: IgG

Information d'application

Indications d'application: ZBP1 antibody can be used for the detection of ZBP1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: ZBP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,4 °C

Stockage commentaire: ZBP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur ZBP1

Antigène: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Autre désignation: ZBP1 (ZBP1 Produits)

Synonymes: anticorps C20orf183, anticorps DAI, anticorps DLM-1, anticorps DLM1, anticorps 2010010H03Rik, anticorps Dai, anticorps Dlm1, anticorps mZaDLM, anticorps ZBP1, anticorps Z-DNA binding protein 1, anticorps ZBP1, anticorps Zbp1

Sujet: ZBP1 Antibody: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK).

Poids moléculaire: Predicted: 39, 45 kDa

Observed: 42 kDa

ID gène: 81030

UniProt: Q9H171