Indoleamine 2,3-Dioxygenase 1 (IDO1) anticorps

Détails pour le produit réf. ABIN1169196, Fournisseur: Connectez-vous pour afficher
Antigène
  • INDO
  • ido
  • indo
  • IDO
  • cd107b
  • IDO1
  • IDO-1
  • Ido
  • Indo
  • indoleamine 2,3-dioxygenase 1
  • indoleamine 2,3-dioxygenase 1 L homeolog
  • indoleamine 2,3-dioxygenase 1-like
  • IDO1
  • ido1.L
  • ido1
  • Ido1
  • LOC100050681
Reactivité
Humain
170
53
33
5
3
3
1
1
Hôte
Lapin
101
67
20
2
2
Clonalité
Polyclonal
Conjugué
Inconjugué
7
7
5
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
143
79
56
37
27
20
14
13
9
4
4
3
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Recombinant human IDO.
Specificité Recognizes human IDO. Detects a band of ~45 kDa by Western blot.
 Réactivité croisée Humain
Stérilité 0.2 μm filtered
Antigène
Autre désignation IDO (IDO1 Antibody Extrait)
Sujet IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.
UniProt P14902
Pathways Activated T Cell Proliferation
Indications d'application Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Agent conservateur Without preservative
Stock 4 °C,-20 °C
Stockage commentaire Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.
Date de péremption 6 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Indoleamine 2,3-Dioxygenase 1 (IDO1) antibody (ABIN1169196) Western blot analysis of human IDO using anti-IDO (human), pAb at 1:2,000 dilution. ...
Produit citée dans: Pietra, Manzini, Rivara, Vitale, Cantoni, Petretto, Balsamo, Conte, Benelli, Minghelli, Solari, Gualco, Queirolo, Moretta, Mingari: "Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity." dans: Cancer research, Vol. 72, Issue 6, pp. 1407-15, 2012 (PubMed).

Opitz, Litzenburger, Opitz, Sahm, Ochs, Lutz, Wick, Platten: "The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells." dans: PLoS ONE, Vol. 6, Issue 5, pp. e19823, 2011 (PubMed).

Curti, Trabanelli, Onofri, Aluigi, Salvestrini, Ocadlikova, Evangelisti, Rutella, De Cristofaro, Ottaviani, Baccarani, Lemoli: "Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells." dans: Haematologica, Vol. 95, Issue 12, pp. 2022-30, 2010 (PubMed).

Maby-El Hajjami, Amé-Thomas, Pangault, Tribut, DeVos, Jean, Bescher, Monvoisin, Dulong, Lamy, Fest, Tarte: "Functional alteration of the lymphoma stromal cell niche by the cytokine context: role of indoleamine-2,3 dioxygenase." dans: Cancer research, Vol. 69, Issue 7, pp. 3228-37, 2009 (PubMed).

Boasso, Herbeuval, Hardy, Anderson, Dolan, Fuchs, Shearer: "HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells." dans: Blood, Vol. 109, Issue 8, pp. 3351-9, 2007 (PubMed).

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