TICAM2 anticorps (AA 2-29)

N° du produit ABIN1169199

Détail du produit anti-TICAM2 anticorps

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Épitope: AA 2-29

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TICAM2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Recognizes human TRAM.

Réactivité croisée: Humain

Immunogène: Synthetic peptide corresponding to aa 2-29 (G2IGKSKINSCPLSLSWGKRHSVDTSPGY29) of human TRAM.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Neat serum containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-TICAM2 (ABIN1169199)

Aksoy, Albarani, Nguyen, Laes, Ruelle, De Wit, Willems, Goldman, Goriely: "Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells." dans: Blood, Vol. 109, Issue 7, pp. 2887-93, (2007) (PubMed).

Détails sur TICAM2

Antigène: TICAM2 (Toll-Like Receptor Adaptor Molecule 2 (TICAM2))

Autre désignation: TRAM (TICAM2 Produits)

Synonymes: anticorps MyD88-4, anticorps TICAM-2, anticorps TIRAP3, anticorps TIRP, anticorps TRAM, anticorps B430113A10, anticorps Tirp, anticorps Trif, anticorps toll like receptor adaptor molecule 2, anticorps toll-like receptor adaptor molecule 2, anticorps TICAM2, anticorps Ticam2

Sujet: TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.

UniProt: Q86XR7

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades