PIDD anticorps

N° du produit ABIN1169269

Cet anticorps Souris Monoclonal détecte spécifiquement PIDD dans WB. Il présente une réactivité avec des échantillons de Souris.

Aperçu rapide pour PIDD anticorps (ABIN1169269)

Antigène: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PIDD est non-conjugé

Application: Western Blotting (WB)

Clone: Lise-1

Détail du produit anti-PIDD anticorps

Fonction: anti-PIDD (mouse), mAb (Lise-1)

Specificité: Recognizes mouse PIDD.

Attributs du produit: Monoclonal Antibody. Recognizes mouse PIDD. Isotype: Mouse IgG2bkappa. Clone: Lise-1. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Pureté: >95 % (SDS-PAGE)

Immunogène: Mouse PIDD (Death Domain).

Isotype: IgG2b kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur PIDD

Antigène: PIDD (P53-Induced Death Domain Protein (PIDD))

Autre désignation: PIDD

Sujet:

Alternate Names/Synonyms: p53-induced Protein with a Death Domain, Leucine-rich Repeat and Death Domain-containing Protein, Lrdd

Product Description: PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

UniProt: Q9ERV7

Pathways: Signalisation p53, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity