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ANGPTL4 anticorps (Coiled coil domain)

ANGPTL4 Reactivité: Humain WB, IHC, ELISA Hôte: Souris Monoclonal Kairos4-397G unconjugated
N° du produit ABIN1169317
  • Antigène Voir toutes ANGPTL4 Anticorps
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Épitope
    • 11
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Coiled coil domain
    Reactivité
    • 55
    • 27
    • 22
    • 4
    • 4
    • 1
    Humain
    Hôte
    • 64
    • 13
    • 2
    Souris
    Clonalité
    • 68
    • 11
    Monoclonal
    Conjugué
    • 54
    • 13
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ANGPTL4 est non-conjugé
    Application
    • 64
    • 37
    • 34
    • 9
    • 6
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Specificité
    Recognizes the coiled-coil domain (CCD) of human ANGPTL4. Detects a band of ~19 kDa by Western blot.
     Réactivité croisée
    Humain
    Stérilité
    0.2 μm filtered
    Immunogène
    Recombinant human coiled-coil domain of ANGPTL4.
    Clone
    Kairos4-397G
    Isotype
    IgG1
    Top Product
    Discover our top product ANGPTL4 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
    Agent conservateur
    Without preservative
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Date de péremption
    12 months
  • Antigène
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Autre désignation
    ANGPTL4 (ANGPTL4 Produits)
    Synonymes
    anticorps ANGPTL2, anticorps ARP4, anticorps FIAF, anticorps HFARP, anticorps NL2, anticorps PGAR, anticorps pp1158, anticorps Arp4, anticorps Bk89, anticorps Fiaf, anticorps Hfarp, anticorps Ng27, anticorps Pgar, anticorps Pgarg, anticorps Pp1158, anticorps ANGPTL4, anticorps fiaf, anticorps im:7144703, anticorps si:rp71-39b20.7, anticorps angiopoietin like 4, anticorps angiopoietin-like 4, anticorps ANGPTL4, anticorps Angptl4, anticorps angptl4
    Sujet
    ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
    UniProt
    Q9BY76
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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