ANGPTL4 anticorps (Coiled coil domain)

N° du produit ABIN1169317

Cet anticorps Souris Monoclonal détecte spécifiquement ANGPTL4 dans WB, IHC et ELISA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ANGPTL4 anticorps (Coiled coil domain) (ABIN1169317)

Antigène: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ANGPTL4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: Kairos4-397G

Détail du produit anti-ANGPTL4 anticorps

Épitope: Coiled coil domain

Specificité: Recognizes the coiled-coil domain (CCD) of human ANGPTL4. Detects a band of ~19 kDa by Western blot.

Réactivité croisée: Humain

Stérilité: 0.2 μm filtered

Immunogène: Recombinant human coiled-coil domain of ANGPTL4.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Agent conservateur: Without preservative

Stock: 4 °C,-20 °C

Stockage commentaire: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Détails sur ANGPTL4

Antigène: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Autre désignation: ANGPTL4

Sujet: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha