NOD1 anticorps (AA 2-31)

N° du produit ABIN1169390

Il existe 1 publication pour ce produit. L’anticorps anti-NOD1 Polyclonal Lapin est utilisé pour la détection de NOD1 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour NOD1 anticorps (AA 2-31) (ABIN1169390)

Antigène: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NOD1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NOD1 anticorps

Épitope: AA 2-31

Fonction: anti-Nod1 (human), pAb (AL184)

Specificité: Recognizes human Nod1.

Attributs du produit: Polyclonal Antibody. Recognizes human Nod1. Source: Rabbit. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. Nod (CARD4) is a cytosolic pattern recognition molecule (PRRs) of the NLR (NOD-like receptor) family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid (meso-DAP)-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.

Immunogène: Synthetic peptide corresponding to aa 2-31 (E2EQGHSEMEIIPSESHPHIQLLKSNRELLV31) of human Nod1.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Stock: 4 °C,-20 °C

Stockage commentaire:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Date de péremption: 12 months

Références pour anticorps anti-NOD1 (ABIN1169390)

Costello, Joyce, Abrahams: "NOD protein expression and function in first trimester trophoblast cells." dans: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 57, Issue 1, pp. 67-80, (2006) (PubMed).

Détails sur NOD1

Antigène: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Autre désignation: Nod1

Sujet:

Alternate Names/Synonyms: CARD4, Caspase Recruitment Domain-containing Protein 4, Nucleotide-binding Oligomerization Domain-containing Protein 1

Product Description: Nod (CARD4) is a cytosolic pattern recognition molecule (PRRs) of the NLR (NOD-like receptor) family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid (meso-DAP)-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.

UniProt: Q8BHB0

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades, Inflammasome