WIPF1 anticorps (pSer488) (PE)

N° du produit ABIN1177221

Cité dans 1 publication. Cet anticorps anti-WIPF1 Monoclonal Souris conjugué à PE (Clone K32-824) (ABIN1177221) détecte spécifiquement WIPF1 dans ICS. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour WIPF1 anticorps (pSer488) (PE) (ABIN1177221)

Antigène: WIPF1 (WAS/WASL Interacting Protein Family, Member 1 (WIPF1))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp WIPF1 est conjugé à/à la PE

Application: Intracellular Staining (ICS)

Clone: K32-824

Détail du produit anti-WIPF1 anticorps (PE)

Épitope: pSer488

Marque: BD Phosflow™

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Phosphorylated Human WIP Peptide

Isotype: IgG1 kappa

Information d'application

Volume d'échantillon: 20 μL

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.

Références pour anticorps anti-WIPF1 (PE) (ABIN1177221)

Aspenström: "The verprolin family of proteins: regulators of cell morphogenesis and endocytosis." dans: FEBS letters, Vol. 579, Issue 24, pp. 5253-9, (2005) (PubMed).

Détails sur WIPF1

Antigène: WIPF1 (WAS/WASL Interacting Protein Family, Member 1 (WIPF1))

Autre désignation: WIP

Sujet: Wiskott-Adrich syndrome protein (WASP)-Interacting Protein (WIP) is a member of the verprolin family of proteins that regulate cytoskeletal organization in a wide variety of cellular activities, including endocytosis, cellular adhesion and migration, mast cell degranulation, and lymphocyte activation. The 503-amino acid WIP protein contains binding sites for actin (globular and filamentous) and other proteins that are involved in the regulation of actin polymerization, such as WASP, N-WASP, profilin, cortactin, Hck, and NCK. As its functions imply, WIP is localized in actin-rich cell structures. The K32-824 monoclonal antibody recognizes the phosphorylated serine 488 (pS488) of human WIP. The orthologous phosphorylation sites in mouse and rat WIP are S478 and S472, respectively.

Pathways: Signalisation RTK