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Ligand
BDNF (Brain-Derived Neurotrophic Factor):
COL11A2 (Collagen, Type XI, alpha 2):
EGF (Epidermal Growth Factor):
FGF6 (Fibroblast Growth Factor 6):
FGF7 (Fibroblast Growth Factor 7):
GDNF (Glial Cell Line Derived Neurotrophic Factor):
NGFB (Nerve Growth Factor beta):
PDGFD (Platelet Derived Growth Factor D):
ATF2 (Activating Transcription Factor 2):
Show all Targets
FGF1 (Fibroblast Growth Factor 1 (Acidic)):
FGF10 (Fibroblast Growth Factor 10):
FGF19 (Fibroblast Growth Factor 19):
FGF2 (Fibroblast Growth Factor 2 (Basic)):
FGF21 (Fibroblast Growth Factor 21):
FGF22 (Fibroblast Growth Factor 22):
FGF23 (Fibroblast Growth Factor 23):
FGF3 (Fibroblast Growth Factor 3):
FGF4 (Fibroblast Growth Factor 4):
FGF5 (Fibroblast Growth Factor 5):
FGF8 (Fibroblast Growth Factor 8 (Androgen-Induced)):
FLT3LG (Fms-Related tyrosine Kinase 3 Ligand):
GDNF (Glial Cell Line Derived Neurotrophic Factor):
GAS6 (Growth Arrest-Specific 6):
HBEGF (Heparin-Binding EGF-Like Growth Factor):
HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor)):
IGF1 (Insulin-Like Growth Factor 1):
PDGFB (Platelet-Derived Growth Factor beta Polypeptide):
PDGFA (Platelet-Derived Growth Factor alpha Polypeptide):
PDGFC (Platelet-Derived Growth Factor C):
TGFA (Transforming Growth Factor, alpha):
TULP1 (Tubby Like Protein 1):
VEGFA (Vascular Endothelial Growth Factor A):
VEGFB (Vascular Endothelial Growth Factor B):
VEGFC (Vascular Endothelial Growth Factor C):
RTK
TYRO3 (TYRO3 Protein Tyrosine Kinase):
AATK (Apoptosis-Associated tyrosine Kinase):
AXL (AXL Receptor tyrosine Kinase):
MERTK (C-Mer Proto-Oncogene Tyrosine Kinase):
FGFR1 (Fibroblast Growth Factor Receptor 1):
FGFR2 (Fibroblast Growth Factor Receptor 2):
MST1R (Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase)):
KIT (Mast/stem Cell Growth Factor Receptor):
ALK (Anaplastic Lymphoma Receptor tyrosine Kinase):
ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase):
CSF1R (Colony Stimulating Factor 1 Receptor):
DDR1 (Discoidin Domain Receptor tyrosine Kinase 1):
Show all Targets
DDR2 (Discoidin Domain Receptor tyrosine Kinase 2):
EPHA10 - EPH Receptor A10:
EGFR (Epidermal Growth Factor Receptor):
FGFR3 (Fibroblast Growth Factor Receptor 3):
FGFR4 (Fibroblast Growth Factor Receptor 4):
FGFRL1 (Fibroblast Growth Factor Receptor-Like 1):
FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1)):
FLT3 (Fms-Related tyrosine Kinase 3):
FLT4 (Fms-Related Tyrosine Kinase 4):
INSRR (Insulin Receptor-Related Receptor):
IGF1R (Insulin-Like Growth Factor 1 Receptor):
LMTK2 (Lemur tyrosine Kinase 2):
LTK (Leukocyte Receptor tyrosine Kinase):
KIT (Mast/stem Cell Growth Factor Receptor):
MME (Membrane Metallo-Endopeptidase):
MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase):
NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3):
PDGFRA (Platelet-Derived Growth Factor Receptor, alpha Polypeptide):
KCNH8 (Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 8):
PTK7 (PTK7 Protein tyrosine Kinase 7):
ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1):
ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2):
RET - Ret Proto-Oncogene:
RYK (RYK Receptor-Like Tyrosine Kinase):
TEK (TEK Tyrosine Kinase, Endothelial):
TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1):
ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian)):
ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2):
ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3):
Adaptors
SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1):
SHC2 (SHC (Src Homology 2 Domain Containing) Transforming Protein 2):
GAB1 (GRB2-Associated Binding Protein 1):
GRB2 (Growth Factor Receptor-Bound Protein 2):
SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3):
GEF
RASGRF1 (Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1):
SOS1 (Son of Sevenless Homolog 1):
SOS2 (Son of Sevenless Homolog 2):
GTPase
RHOG (Ras Homolog Family Member G):
RAC2 (Ras-Related C3 Botulinum Toxin Substrate 2 (Rho Family, Small GTP Binding Protein Rac2)):
CDC42 (Cell Division Cycle 42 (GTP Binding Protein, 25kDa)):
HRAS (HRas proto-oncogene, GTPase):
RAC3 (Ras-Related C3 Botulinum Toxin Substrate 3 (Rho Family, Small GTP Binding Protein Rac3)):
Inhibitor
DEPTOR (DEP Domain Containing mTOR-Interacting Protein):
TSC1 (Tuberous Sclerosis 1):
Kinase
PAK1 (P21-Activated Kinase 1):
PAK2 (P21-Activated Kinase 2):
PAK4 (P21-Activated Kinase 4):
AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1):
AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2):
AKT3 (V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma)):
PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide):
PDK1 (Pyruvate Dehydrogenase Kinase 1):
PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2):
RPS6KB1 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1):
RPS6KB2 (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2):
Messenger
Phosphatase
PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform):
PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11):
PPP3CB (Protein Phosphatase 3, Catalytic Subunit, beta Isozyme):
PPP3CC (Protein Phosphatase 3, Catalytic Subunit, gamma Isozyme):
PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha):
Phospholipase
PLCG2 - Phospholipase C gamma 2:
PLCG1 - Phospholipase C gamma 1:
Pro-apoptotic
BAD (BCL2-Associated Agonist of Cell Death):
Protease
Protein kinase
IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta):
IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma):
ARAF (V-Raf Murine Sarcoma 3611 Viral Oncogene Homolog):
BRAF (B-Raf proto-oncogene, serine/threonine kinase):
RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1):
Regulator
GBL (G protein beta subunit-like):
RHEB (Ras Homolog Enriched in Brain):
Transcription factor
NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1):
STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa):
STAT3 (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor)):
NFAT5 (Nuclear Factor of Activated T-Cells 5, Tonicity-Responsive):
NFAT1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2):
NFATC3 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 3):
NFATC4 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 4):
NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1):
STAT5A (Signal Transducer and Activator of Transcription 5A):
STAT5B (Signal Transducer and Activator of Transcription 5B):
RELB (V-Rel Reticuloendotheliosis Viral Oncogene Homolog B):
Others
ARPC1B (Actin Related Protein 2/3 Complex, Subunit 1B, 41kDa):
ACTR2 (Actin-Related Protein 2):
NCKAP1 (NCK Associated Protein 1):
CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2):
ARPC2 (Actin Related Protein 2/3 Complex, Subunit 2, 34kDa):
ARPC3 (Actin Related Protein 2/3 Complex, Subunit 3, 21kDa):
ARPC4 (Actin Related Protein 2/3 Complex, Subunit 4, 20kDa):
ARPC5 (Actin Related Protein 2/3 Complex, Subunit 5, 16kDa):
ACTR3 (ARP3 Actin-Related Protein 3):
BRK1 (BRICK1, SCAR/WAVE Actin-Nucleating Complex Subunit):
WASF1 (WAS Protein Family, Member 1):
WASF2 (WAS Protein Family, Member 2):
WASF3 (WAS Protein Family, Member 3):
WIPF1 (WAS/WASL Interacting Protein Family, Member 1):