Integrin alpha 1 anticorps

N° du produit ABIN1177273

Cet anticorps Hamster arménien Monoclonal détecte spécifiquement Integrin alpha 1 dans WB, IP, FACS, IHC (fro), BR et IHC (f). Il présente une réactivité avec des échantillons de Souris et Rat. Il a été cité dans 3+ publications.

Aperçu rapide pour Integrin alpha 1 anticorps (ABIN1177273)

Antigène: Integrin alpha 1 (ITGA1)

Reactivité: Souris, Rat

Hôte: Hamster arménien

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin alpha 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: Ha31-8

Détail du produit anti-Integrin alpha 1 anticorps

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Immunogène: Rat Emulsified Lewis Rat Glomeruli Cells

Isotype: IgG2 lambda

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Références pour anticorps anti-Integrin alpha 1 (ABIN1177273)

Mendrick, Kelly, duMont, Sandstrom: "Glomerular epithelial and mesangial cells differentially modulate the binding specificities of VLA-1 and VLA-2." dans: Laboratory investigation; a journal of technical methods and pathology, Vol. 72, Issue 3, pp. 367-75, (1995) (PubMed).

Miyake, Sakurai, Okumura, Yagita: "Identification of collagen and laminin receptor integrins on murine T lymphocytes." dans: European journal of immunology, Vol. 24, Issue 9, pp. 2000-5, (1994) (PubMed).

Hemler: "VLA proteins in the integrin family: structures, functions, and their role on leukocytes." dans: Annual review of immunology, Vol. 8, pp. 365-400, (1990) (PubMed).

Détails sur Integrin alpha 1

Antigène: Integrin alpha 1 (ITGA1)

Autre désignation: CD49a

Sujet: The Ha31/8 antibody reacts with the 180-kDa integrin alpha1 chain (CD49a), which is a transmembrane glycoprotein that non-covalently associates with the integrin beta1 subunit (CD29) to form the alpha1beta1 (complex known as VLA-1). VLA-1 has been reported to be expressed on activated T cells, monocytes, smooth muscle cells, and endothelial cells. It is a receptor for collagen and laminin. The Ha31/8 monoclonal antibody is specific for both rat and mouse CD49a. It has been reported that Ha31/8 antibody can block VLA-1-mediated binding of rat cells to collagen.
Synonyms: Integrin alpha1 chain

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex