CD72 anticorps

N° du produit ABIN118793

L’anticorps Souris Monoclonal anti-CD72 a été validé pour FACS et IP. Il convient pour détecter CD72 dans des échantillons de Humain.

Aperçu rapide pour CD72 anticorps (ABIN118793)

Antigène: CD72 (CD72 Molecule (CD72))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD72 est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: 3F3

Détail du produit anti-CD72 anticorps

Specificité: The antibody reacts with CD72, a 39-43 kDa type II membrane glycoprotein (C-type lectin family).

Purification: Precipitation methods and ion exchange chromatography

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Normal human lymphocytes from a lymph node

Isotype: IgG2b

Information d'application

Indications d'application: Immunoprecipitation. Flow Cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing. Dilute only prior to immediate use

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody (undiluted) at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD72

Antigène: CD72 (CD72 Molecule (CD72))

Autre désignation: CD72

Sujet: CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation. CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.Synonyms: B-Cell marker, B-cell differentiation antigen CD72, Ly-32, Ly32, Lyb-2, Lymphocyte antigen 32

ID gène: 971

NCBI Accession: NP_001773

UniProt: P21854

Pathways: BCR Signaling