CD130/gp130 anticorps

N° du produit ABIN120026

L’anticorps anti-CD130/gp130 Monoclonal Souris est utilisé pour la détection de CD130/gp130 dans des échantillons de Humain. Il a été validé pour FACS et EIA.

Aperçu rapide pour CD130/gp130 anticorps (ABIN120026)

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD130/gp130 est non-conjugé

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: B-T2

Détail du produit anti-CD130/gp130 anticorps

Specificité: This antibody specifically recognises soluble and membrane bound gp130 receptor. This antibody has been reported to block the activity of IL-6.

Purification: Ion exchange chromatography

Immunogène: Natural soluble gp130 receptor. Spleen cells from immunised BALB/c (Iffa Credo) mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.

Isotype: IgG1

Information d'application

Indications d'application: ELISA. Flow Cytometry: 0.2 μg/106cells, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CD130/gp130

Antigène: CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))

Autre désignation: CD130 / IL6ST

Sujet: CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta

ID gène: 3572

NCBI Accession: NP_002175

UniProt: P40189

Pathways: Signalistation JAK/STAT, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints