ADRB3 anticorps (Cytoplasmic Domain)

N° du produit ABIN122007

Cet anticorps anti-ADRB3 est un anticorps Lapin Polyclonal détectant ADRB3 dans IHC (p). Adapté pour Humain.

Aperçu rapide pour ADRB3 anticorps (Cytoplasmic Domain) (ABIN122007)

Antigène: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRB3 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ADRB3 anticorps

Épitope: Cytoplasmic Domain

Specificité: Reacts with Beta-3 Adrenoceptor (Family: GPCR, Subfamily: Adrenergic)

Purification: Peptide immunogen affinity column

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunohistochemistry on formalin fixed paraffin embedded tissues: 36 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur ADRB3

Antigène: ADRB3 (Adrenergic, beta-3-, Receptor (ADRB3))

Autre désignation: beta-3 Adrenergic Receptor

Sujet: The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility, beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure, ADRB3 is also one of the molecular targets under active research in the treatment of obesity. Beta-3 adrenoceptor expression has been documented in adipose, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of ADRB3. ESTs have been isolated from heart/melanocyte/uterus and placenta librariesSynonyms: ADRB3, ADRB3R, B3AR, Beta-3 adrenoceptor

ID gène: 155

UniProt: P13945

Pathways: cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Brown Fat Cell Differentiation