CCR2 anticorps
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- Antigène Voir toutes CCR2 Anticorps
- CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CCR2 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificité
- Reacts with CCR2 (family: GPCR, subfamily: Chemokine).
- Purification
- Peptide immunogen affinity column
- Immunogène
- Synthetic peptide - KLH conjugated
- Top Product
- Discover our top product CCR2 Anticorps primaire
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- Indications d'application
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Immunohistochemistry with formalin fixed paraffin embedded tissues: 3-30 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International. - Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS, pH 7.7, containing 0.01 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-80 °C
- Stockage commentaire
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. - Date de péremption
- 12 months
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- Antigène
- CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))
- Autre désignation
- CD192 / CCR2 (CCR2 Produits)
- Synonymes
- anticorps CC-CKR-2, anticorps CCR-2, anticorps CCR2A, anticorps CCR2B, anticorps CD192, anticorps CKR2, anticorps CKR2A, anticorps CKR2B, anticorps CMKBR2, anticorps MCP-1-R, anticorps ACKR5, anticorps CKRX, anticorps CRAM, anticorps CRAM-A, anticorps CRAM-B, anticorps HCR, anticorps Cc-ckr-2, anticorps Ccr2a, anticorps Ccr2b, anticorps Ckr2, anticorps Ckr2a, anticorps Ckr2b, anticorps Cmkbr2, anticorps mJe-r, anticorps C-C motif chemokine receptor 2, anticorps C-C motif chemokine receptor like 2, anticorps chemokine (C-C motif) receptor 2, anticorps CCR2, anticorps CCRL2, anticorps Ccr2, anticorps LOC484790
- Sujet
- CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage trafficking and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis (Ruth et al., 2001). ESTs have been isolated from liver/spleen and prostate libraries.Synonyms: C-C CKR-2, C-C chemokine receptor type 2, CC-CKR-2, CCR-2, CMKBR2, MCP1-Receptor, Monocyte chemoattractant protein 1 receptor
- ID gène
- 729230
- UniProt
- P41597
- Pathways
- cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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