CCR2 anticorps

N° du produit ABIN122022

Cet anticorps anti-CCR2 Polyclonal Lapin (ABIN122022) détecte spécifiquement CCR2 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CCR2 anticorps (ABIN122022)

Antigène: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCR2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CCR2 anticorps

Specificité: Reacts with CCR2 (family: GPCR, subfamily: Chemokine).

Purification: Peptide immunogen affinity column

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunohistochemistry with formalin fixed paraffin embedded tissues: 3-30 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CCR2

Antigène: CCR2 (Chemokine (C-C Motif) Receptor 2 (CCR2))

Autre désignation: CD192 / CCR2

Sujet: CCR2, a Chemokine Receptor, is a regulator of monocyte/macrophage trafficking and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis (Boring et al., 1998) and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis (Ruth et al., 2001). ESTs have been isolated from liver/spleen and prostate libraries.Synonyms: C-C CKR-2, C-C chemokine receptor type 2, CC-CKR-2, CCR-2, CMKBR2, MCP1-Receptor, Monocyte chemoattractant protein 1 receptor

ID gène: 729230

UniProt: P41597

Pathways: cAMP Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process