LHCGR anticorps (C-Term)

N° du produit ABIN122503

Cet anticorps Lapin Polyclonal détecte spécifiquement LHCGR dans IHC (p). Il présente une réactivité envers Humain et Rat et a été mentionné dans 1 publication.

Aperçu rapide pour LHCGR anticorps (C-Term) (ABIN122503)

Antigène: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LHCGR est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-LHCGR anticorps

Épitope: C-Term

Réactivité croisée (Details): Species reactivity (expected):Rat.
Species reactivity (tested):Human.

Purification: Peptide Immunogen Affinity Chromatography.

Immunogène: Synthetic peptide - KLH conjugated. Epitope: C-terminal domain of human. Remarks: The immunizing peptide shows 78% identity (84% similarity) with Mouse and 94% identity (100% similarity) with Rat.

Information d'application

Indications d'application: Immunohistochemistry with Formalin Fixed Paraffin Embedded Tissues (5 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Date de péremption: 12 months

Références pour anticorps anti-LHCGR (ABIN122503)

Sand, Bergvall, Ekblad, DAmato, Ohlsson: "Expression and distribution of GnRH, LH, and FSH and their receptors in gastrointestinal tract of man and rat." dans: Regulatory peptides, Vol. 187, pp. 24-8, (2013) (PubMed).

Détails sur LHCGR

Antigène: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Autre désignation: Luteinizing Hormone Receptor (LHCGR)

Sujet: LHCGR is a Glycoprotein Hormone Receptor for both luteinizing hormone and choriogonadotropin. It is expressed in the reproductive organs of both males and females. In males, the luteinizing hormone/choriogonadotropin receptor is involved in the development and function of Leydig cells. Mutations in this gonadotropin receptor can result in disorders of male secondary sexual character development, such as familial male precocious puperty and male pseudohermaphroditism, or lead to adenomas of the testis. In females, inactivating mutations of LHCGR cause hypergonadotrophic hypogonadism with primary amenorrhea or oligomenorrhea, cystic ovaries, and infertility. LHCGR has many alternatively spliced isoforms that affect where this gene is expressed. LHCGR has been reported in brain, cervix, epididymis, ovary, placenta, prostate, testis, umbilical cord, and uterus. ESTs have been isolated from fetal lung/testis/B-cell and testis libraries.Synonyms: LCGR, LGR2, LH/CG-R, LHCGR, LHR, LHRHR, LSH-R, Luteinizing hormone receptor, Lutropin-choriogonadotropic hormone receptor

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling