CCR8 anticorps

N° du produit ABIN122580

Cet anticorps anti-CCR8 Polyclonal Lapin (ABIN122580) détecte spécifiquement CCR8 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CCR8 anticorps (ABIN122580)

Antigène: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCR8 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CCR8 anticorps

Specificité: Reacts with C-C Chemokine Receptor 8 (CCR8) (family: GPCR, subfamily: Chemokine)

Purification: Peptide immunogen affinity column

Immunogène: Synthetic peptide - KLH conjugated

Information d'application

Indications d'application: Immunohistochemistry with formalin fixed paraffin embedded tissues: 28 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur CCR8

Antigène: CCR8 (Chemokine (C-C Motif) Receptor 8 (CCR8))

Autre désignation: CDw198 / CCR8

Sujet: CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces endothelial chemotaxis and may function as an HIV-1 co-receptor on primary human cells, contributing to HIV-1-induced thymic pathogenesis. CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. Increased expression has been seen in allergen-challenged atopic asthma. No CCR8 expression was found in mesangial cells of the kidney cortex. ESTs have been isolated from human normal kidney, eye, and B cell/lung/testis libraries and from human brain, germ cell, and pancreas cancer libraries.Synonyms: C-C CKR-8, C-C chemokine receptor type 8, CC-CKR-8, CC-chemokine receptor CHEMR1, CCR-8, CKRL1, CMKBR8, CMKBRL2, Chemokine receptor-like 1, GPR-CY6, TER1

ID gène: 1237

UniProt: P51685