MAPT anticorps (Isoform 13, N-Term)

N° du produit ABIN126938

L’anticorps Souris Monoclonal anti-MAPT a été validé pour WB, IP et IHC (p). Il convient pour détecter MAPT dans des échantillons de Humain.

Aperçu rapide pour MAPT anticorps (Isoform 13, N-Term) (ABIN126938)

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: C45

Détail du produit anti-MAPT anticorps

Épitope: Isoform 13, N-Term

Attributs du produit: Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein,Paired helical filament-tau

Purification: Affinity Purified

Immunogène: Synthetic peptide corresponding to the N-terminus of of the longest isoform of Human Tau.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot: 1/1000. Immunoprecipitation: 1/500. Immunohistochemistry: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 50 % Glycerol, 1 % BSA and 0.02 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT / tau

Sujet: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

UniProt: P10636

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size