ILK anticorps (C-Term)

N° du produit ABIN127105

Cet anticorps Lapin Polyclonal détecte spécifiquement ILK dans WB et IHC (p). Il présente une réactivité envers Humain, Souris et Rat.

Aperçu rapide pour ILK anticorps (C-Term) (ABIN127105)

Antigène: ILK (Integrin-Linked Kinase (ILK))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ILK est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ILK anticorps

Épitope: C-Term

Specificité: The antibody recognizes 51 kDa of ILK1.

Purification: Antigen affinity chromatography

Immunogène: Synthetic peptide corresponding to the C-terminus of human ILK-1.

Information d'application

Indications d'application: Western Blot: 0.5-4 μg/mL. Immunohistochemistry: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Détails sur ILK

Antigène: ILK (Integrin-Linked Kinase (ILK))

Autre désignation: Integrin-Linked Protein Kinase

Sujet: ILKs (Integrin-linked kinases) in combination with integrins and growth factors regulate cell survival, cell cycle, cell-cell adhesion and cell motility. ILK functions as a scaffold bridging the extra-cellular matrix (ECM) and growth factor receptors to the actin cytoskeleton through interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin. ILK phosphorylates several cellular targets including Akt, GSK-3, myosin light chain 2, as well as affixin. These phosphorylation events are key regulatory steps in modulating the activities of the targets.Synonyms: 59 kDa serine/threonine-protein kinase, ILK, ILK-1, ILK-2, ILK1, ILK2, p59ILK

ID gène: 3611

NCBI Accession: NP_001014794

UniProt: Q13418

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration