MAP3K11 anticorps (C-Term)

N° du produit ABIN127111

Détail du produit anti-MAP3K11 anticorps

Antigène: MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP3K11 est non-conjugé

Application: Western Blotting (WB)

Specificité: The antibody recognizes 92 kDa MLK3. It does not cross react with MLK1, MLK2 and other mixed lineage kinases.

Purification: Affinity purified

Immunogène: Synthetic peptide mapping to the C-terminus of human MLK3.

Information d'application

Indications d'application: Western Blot: 0.5-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 50 % glycerol, 1 % BSA, and 0.02 % thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C/-80 °C

Stockage commentaire: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Détails sur MAP3K11

Antigène: MAP3K11 (Mitogen-Activated Protein Kinase Kinase Kinase 11 (MAP3K11))

Autre désignation: MAP3K11 (MAP3K11 Produits)

Synonymes: anticorps MEKK11, anticorps MLK-3, anticorps MLK3, anticorps PTK1, anticorps SPRK, anticorps 2610017K16Rik, anticorps Mlk3, anticorps Mlk-3, anticorps RHOE, anticorps mitogen-activated protein kinase kinase kinase 11, anticorps MAP3K11, anticorps Map3k11

Sujet: MLK3 (Mixed lineage kinase 3) is a serine/threonine kinase that has an amino-terminal SH3 domain followed by the kinase domain and two leucine zippers, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. MLK3 functions as a MAPKKK of the SAPK/JNK stress pathway by directly phosphorylating SEK1/MKK4 and MKK7, although it is controversial whether MLK3 is involved in p38 stress pathway activation. MLK3 also functions as an IκB kinase and mediates the activation of the transcriptional factor NF-κB stimulated by CD3/CD28, suggesting a role for MLK3 in immune and inflammatory responses.Synonyms: MLK3, Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, PTK1, Src-homology 3 domain-containing proline-rich kinase

ID gène: 4296

NCBI Accession: NP_002410

UniProt: Q16584

Pathways: Signalisation MAPK, Interferon-gamma Pathway