The antibody detects 36 kDa annexin VIII of Human origin. The ~28-30 kDa cleavage fragments can also be detected in Jurkat cell lysate. Blocking peptide is available separately (AP00292CP-N).
Purification
Protein A Affinity Chromatography
Immunogène
Synthetic peptide surrounding amino acid 316 of Human Annexin VIII.
ANXA8
Reactivité: Humain
WB, FACS
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
Western Blot: 0.5-4 μg/mL, Jurkat cell lysate can be used as a positive control. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C/-80 °C
Stockage commentaire
Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
Antigène
Annexin VIII (ANXA8)
(Annexin A8 (ANXA8))
Autre désignation
Annexin A8 / ANXA8
Sujet
The annexin family of calcium-binding proteins is composed of at least ten mammalian genes. It is characterized by a conserved core domain which binds to phospholipids in a Ca2+-dependent manner. Annexin family members have been implicated as regulators of diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. Annexin VIII is preferentially expressed in acute promyelocytic leukemia (APL) cells which may relate its role in hematopoietic cell differentiation.Synonyms: ANX8, Annexin VIII, Annexin-8, VAC-beta, Vascular anticoagulant-beta