Cyclin E2 anticorps (C-Term)

N° du produit ABIN129714

Détail du produit anti-Cyclin E2 anticorps

Antigène: Cyclin E2 (CCNE2)

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin E2 est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Attributs du produit: Concentration Definition: by UV absorbance at 280 nm

Immunogène: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids at the of the Cyclin E2 protein.

Isotype: IgG

Information d'application

Indications d'application: This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 50 kDa in size corresponding to Cyclin E2 protein by western blotting in the appropriate cell lysate or extract.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.17 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur Cyclin E2

Antigène: Cyclin E2 (CCNE2)

Autre désignation: Cyclin E2 (CCNE2 Produits)

Synonymes: anticorps ccne2, anticorps MGC53684, anticorps MGC132360, anticorps cb165, anticorps sb:cb165, anticorps zgc:86724, anticorps CCNE2, anticorps cyce2, anticorps CYCE2, anticorps cyclin E2, anticorps cyclin E2 L homeolog, anticorps cyclin E1 L homeolog, anticorps CCNE2, anticorps ccne2.L, anticorps ccne2, anticorps ccne1.L, anticorps Ccne2

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Cyclin E was first identified by its ability to rescue growth of yeast deficient in G1 Cyclins, indicating a role in G1 or G1/S transitions.  Over-expression of Cyclin E has been observed in a variety of human tumors. Multiple isoforms of Cyclin E are expressed in tumors but not in normal tissues, suggesting a post-transcriptional regulation of Cyclin E.  Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27Kip1 and p21Cip1.  The catalytic activity associated with Cyclin E2 complexes is cell cycle regulated and peaks at the G1/S transition.  Unlike Cyclin E1, which is expressed in most proliferating normal and tumor cells, Cyclin E2 levels were low to undetectable in non-transformed cells and increased significantly in tumor-derived cells.
Synonyms: G1/S-specific cyclin-E2

ID gène: 12448, 3769612

UniProt: Q9Z238

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases