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CD33 anticorps

CD33 Reactivité: Humain, Non-Human Primate FACS, WB, IP, IHC (fro), ICC, CyTOF Hôte: Souris Monoclonal WM53 unconjugated
N° du produit ABIN1302476
  • Antigène Voir toutes CD33 Anticorps
    CD33
    Reactivité
    • 173
    • 35
    • 15
    • 13
    • 6
    • 6
    • 3
    • 1
    Humain, Non-Human Primate
    Hôte
    • 100
    • 79
    Souris
    Clonalité
    • 95
    • 83
    • 1
    Monoclonal
    Conjugué
    • 59
    • 17
    • 14
    • 13
    • 11
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD33 est non-conjugé
    Application
    • 107
    • 106
    • 45
    • 35
    • 26
    • 26
    • 22
    • 22
    • 15
    • 12
    • 11
    • 9
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Cytometry by Time of Flight (CyTOF)
    Specificité
    The mouse monoclonal antibody WM53 reacts with an extracellular epitope of CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells, it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
    Réactivité croisée (Details)
    Human, Non-Human Primates
    Purification
    Purified by protein-A affinity chromatography.
    Pureté
    > 95 % (by SDS-PAGE)
    Immunogène
    Human AML cells
    Clone
    WM53
    Isotype
    IgG1
    Top Product
    Discover our top product CD33 Anticorps primaire
  • Indications d'application
    Immunohistochemistry (frozen sections): Acetone fixation.
    Flow cytometry: Recommended dilution: 1-4 μg/mL
    Restrictions
    For Research Use only
  • Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Do not freeze.
  • Leone, Rutella, Bonanno, Abbate, Rebuzzi, Giovannini, Lombardi, Galiuto, Liuzzo, Andreotti, Lanza, Contemi, Leone, Crea: "Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function." dans: European heart journal, Vol. 26, Issue 12, pp. 1196-204, (2005) (PubMed).

    Garnache-Ottou, Chaperot, Biichle, Ferrand, Remy-Martin, Deconinck, de Tailly, Bulabois, Poulet, Kuhlein, Jacob, Salaun, Arock, Drenou, Schillinger, Seilles, Tiberghien, Bensa, Plumas, Saas: "Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells." dans: Blood, Vol. 105, Issue 3, pp. 1256-64, (2005) (PubMed).

    Schenk, Bouchon, Birrer, Colonna, Mueller: "Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 1, pp. 517-24, (2004) (PubMed).

    Shin, Choi, Kim, Chung, Chung, Park, Jung, Kim, Park, Kim, Park, Min, Kim, Park: "Expression of leukemia-associated antigen, JL1, in bone marrow and thymus." dans: The American journal of pathology, Vol. 158, Issue 4, pp. 1473-80, (2001) (PubMed).

    Vitale, Romagnani, Puccetti, Olive, Costello, Chiossone, Pitto, Bacigalupo, Moretta, Mingari: "Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 10, pp. 5764-9, (2001) (PubMed).

    Bradstock, Kirk, Grimsley, Kabral, Hughes: "Unusual immunophenotypes in acute leukaemias: incidence and clinical correlations." dans: British journal of haematology, Vol. 72, Issue 4, pp. 512-8, (1989) (PubMed).

    Favaloro, Bradstock, Kabral, Grimsley, Zowtyj, Zola et al.: "Further characterization of human myeloid antigens (gp160,95; gp150; gp67): investigation of epitopic heterogeneity and non-haemopoietic distribution using panels of monoclonal antibodies belonging ..." dans: British journal of haematology, Vol. 69, Issue 2, pp. 163-71, (1988) (PubMed).

    Favaloro, Bradstock, Kabral, Grimsley, Berndt: "Characterization of monoclonal antibodies to the human myeloid-differentiation antigen, 'gp67' (CD-33)." dans: Disease markers, Vol. 5, Issue 4, pp. 215-25, (1988) (PubMed).

  • Antigène
    CD33
    Autre désignation
    CD33 (CD33 Produits)
    Synonymes
    anticorps SIGLEC-3, anticorps SIGLEC3, anticorps p67, anticorps Siglec-3, anticorps gp67, anticorps CD33 molecule, anticorps CD33 antigen, anticorps CD33, anticorps Cd33
    Sujet
    CD33 Molecule,CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.,SIGLEC3, p67
    ID gène
    945
    UniProt
    P20138
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