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CD79a anticorps (AA 202-216) (FITC)

CD79A Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Poulet, Cheval, Lapin, Cobaye, Opossum FACS Hôte: Souris Monoclonal HM57 FITC
N° du produit ABIN1302907
  • Antigène Voir toutes CD79a (CD79A) Anticorps
    CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
    Épitope
    • 68
    • 25
    • 11
    • 10
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 202-216
    Reactivité
    • 191
    • 101
    • 80
    • 51
    • 50
    • 32
    • 27
    • 25
    • 25
    • 25
    • 16
    • 9
    • 5
    • 5
    • 2
    • 1
    Humain, Souris, Rat, Boeuf (Vache), Porc, Poulet, Cheval, Lapin, Cobaye, Opossum
    Hôte
    • 105
    • 100
    • 3
    • 1
    Souris
    Clonalité
    • 126
    • 82
    • 1
    Monoclonal
    Conjugué
    • 93
    • 19
    • 16
    • 15
    • 14
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CD79a est conjugé à/à la FITC
    Application
    • 118
    • 97
    • 64
    • 58
    • 46
    • 25
    • 22
    • 15
    • 10
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Specificité
    The antibody HM57 interacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
    Réactivité croisée (Details)
    Human, Porcine, Mouse, Rat, Bovine, Equine (Horse), Guinea pig, Opossum, Rabbit, Chicken, Other not determined
    Purification
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogène
    Synthetic peptide corresponding to amino acids 202-216 of human CD79a
    Clone
    HM57
    Isotype
    IgG1
    Top Product
    Discover our top product CD79A Anticorps primaire
  • Indications d'application
    Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining.
    Commentaires

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Restrictions
    For Research Use only
  • Reconstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Do not freeze.
    Avoid prolonged exposure to light.
    Stock
    4 °C
    Stockage commentaire
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Faldyna, Samankova, Leva, Cerny, Oujezdska, Rehakova, Sinkora: "Cross-reactive anti-human monoclonal antibodies as a tool for B-cell identification in dogs and pigs." dans: Veterinary immunology and immunopathology, Vol. 119, Issue 1-2, pp. 56-62, (2007) (PubMed).

    Mason, Cordell, Brown, Borst, Jones, Pulford, Jaffe, Ralfkiaer, Dallenbach, Stein: "CD79a: a novel marker for B-cell neoplasms in routinely processed tissue samples." dans: Blood, Vol. 86, Issue 4, pp. 1453-9, (1995) (PubMed).

    Jones, Cordell, Beyers, Tse, Mason: "Detection of T and B cells in many animal species using cross-reactive anti-peptide antibodies." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 150, Issue 12, pp. 5429-35, (1993) (PubMed).

    Mason, van Noesel, Cordell, Comans-Bitter, Micklem, Tse, van Lier, van Dongen: "The B29 and mb-1 polypeptides are differentially expressed during human B cell differentiation." dans: European journal of immunology, Vol. 22, Issue 10, pp. 2753-6, (1992) (PubMed).

    Mason, Cordell, Tse, van Dongen, van Noesel, Micklem, Pulford, Valensi, Comans-Bitter, Borst: "The IgM-associated protein mb-1 as a marker of normal and neoplastic B cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 2474-82, (1991) (PubMed).

    van Noesel, van Lier, Cordell, Tse, van Schijndel, de Vries, Mason, Borst: "The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 11, pp. 3881-8, (1991) (PubMed).

  • Antigène
    CD79a (CD79A) (B-cell antigen receptor complex-associated protein alpha chain (CD79A))
    Autre désignation
    CD79a (CD79A Produits)
    Synonymes
    anticorps CD79A, anticorps Ig-alpha, anticorps Iga, anticorps Igalpha, anticorps Ly-54, anticorps Ly54, anticorps mb-1, anticorps IGA, anticorps MB-1, anticorps IG-alpha, anticorps CD79a molecule, anticorps CD79A antigen (immunoglobulin-associated alpha), anticorps Cd79a molecule-like, anticorps CD79A, anticorps Cd79a, anticorps Cd79al
    Sujet
    CD79a molecule,CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.,BCR alpha, Ig-alpha, MB-1, IGA
    ID gène
    973
    UniProt
    P11912
    Pathways
    BCR Signaling
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