PDGFRB anticorps (PE)

N° du produit ABIN1303108

Détail du produit anti-PDGFRB anticorps (PE)

Antigène: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDGFRB est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Specificité: The monoclonal antibody 18A2 recognizes an extracellular epitope of CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.

Réactivité croisée (Details): Human

Purification: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogène: CD140b-transfected NIH 3T3 cells

Clone: 18A2

Isotype: IgG1

Information d'application

Indications d'application: Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.

Commentaires:

The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

Restrictions: For Research Use only

Stockage

Reconstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.
Avoid prolonged exposure to light.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Références pour anticorps anti-PDGFRB (PE) (ABIN1303108)

Fekete, Rojewski, Fürst, Kreja, Ignatius, Dausend, Schrezenmeier: "GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC." dans: PLoS ONE, Vol. 7, Issue 8, pp. e43255, (2012) (PubMed).

Détails sur PDGFRB

Antigène: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Abstract: PDGFRB Produits

Synonymes: anticorps AI528809, anticorps CD140b, anticorps PDGFR-1, anticorps Pdgfr, anticorps CD140B, anticorps IBGC4, anticorps JTK12, anticorps PDGFR, anticorps PDGFR1, anticorps platelet derived growth factor receptor, beta polypeptide, anticorps platelet derived growth factor receptor beta, anticorps Pdgfrb, anticorps PDGFRB

Sujet: Platelet derived growth factor receptor beta,CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.,PDGFRB, PDGFR1

ID gène: 5159

UniProt: Q59F04

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling