BCL2L1 anticorps (BCL2-Like 1)

Details for Product anti-BCL2L1 Antibody No. ABIN135021
Antigène
  • BCL-XL/S
  • BCL2L
  • BCLX
  • BCLXL
  • BCLXS
  • Bcl-X
  • PPP1R52
  • bcl-xL
  • bcl-xS
  • Bcl(X)L
  • Bcl-XL
  • Bcl-Xs
  • Bcl2l
  • BclX
  • bcl-x
  • Bcl-xl
  • Bclx
  • bcl-X
  • Bcl-xL
  • BCL-XL
  • BCL2L1
  • bcl-XL
  • bcl-x(l)
  • bcl-xl/s
  • bcl-xs
  • bcl2l
  • bclx
  • bclxl
  • xR11
  • bcl-xl
  • blp1
  • cb1021
  • zfBLP1
  • BCL2 like 1
  • BCL2-like 1
  • Bcl2-like 1
  • BCL2-like 1 L homeolog
  • bcl2-like 1
  • BCL2L1
  • Bcl2l1
  • bcl2l1
  • bcl2l1.L
Reactivité
Humain
463
325
304
117
25
18
13
12
11
9
9
6
3
2
1
Hôte
Souris
305
187
3
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp BCL2L1 est non-conjugé
29
13
10
8
8
8
8
8
8
7
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
350
178
157
131
106
75
63
52
27
21
12
11
9
7
4
4
3
2
1
1
Options
Immunogène Recombinant human Bcl-xS
Clone 7B2-5
Isotype IgG3
Specificité Human/Mouse/Rat/Rhesus Bcl-xL
Attributs du produit Mouse Anti-Bcl-xL-UNLB
Purification Purified
Plasmids, Primers & others Plasmids, Primers & others BCL2L1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Bcl-xL (BCL2L1 Antibody Extrait)
Sujet Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.
Pathways Apoptose, Negative Regulation of intrinsic apoptotic Signaling
Indications d'application
  • Applications: FC - Quality tested , IHC-PS - Reported in literature , ICC - Reported in literature , WB - Reported in literature , IP - Reported in literature , ELISA - Reported in literature
  • Working Dilutions: Flow Cytometry FITC and BIOT conjugates 3 g/106 cells PE conjugate 0.3 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L Immunoblotting Purified (UNLB) antibody 1 g/mL
Volume d'échantillon 1 mL
Restrictions For Research Use only
Concentration 0.1 mg/mL
Buffer 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added
Agent conservateur Without preservative
Conseil sur la manipulation Each reagent is stable for the period shown on the bottle label if stored as directed.
Stock 4 °C
Stockage commentaire Store at 2-8°C
Images (Fournisseur)
Image no. 1 for anti-BCL2-Like 1 (BCL2L1) antibody (ABIN135021) anti-BCL2-Like 1 (BCL2L1) antibody
Produit citée dans: Gottschalk, Boise, Oltvai, Accavitti, Korsmeyer, Quintáns, Thompson: "The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." dans: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, 2006 (PubMed).

Background publications Cheng, Levine, Boise, Thompson, Hardwick: "Bax-independent inhibition of apoptosis by Bcl-XL." dans: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Rajah, Bhala, Nunn, Peehl, Cohen: "7S nerve growth factor is an insulin-like growth factor-binding protein protease." dans: Endocrinology, Vol. 137, Issue 7, pp. 2676-82, 1996 (PubMed).

Chittenden, Harrington, OConnor, Flemington, Lutz, Evan, Guild: "Induction of apoptosis by the Bcl-2 homologue Bak." dans: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Kiefer, Brauer, Powers, Wu, Umansky, Tomei, Barr: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." dans: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Yin, Oltvai, Korsmeyer: "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax." dans: Nature, Vol. 369, Issue 6478, pp. 321-3, 1994 (PubMed).

Cohen: "Programmed cell death in the immune system." dans: Advances in immunology, Vol. 50, pp. 55-85, 1991 (PubMed).

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