VCAM1 anticorps

N° du produit ABIN135070

Détail du produit anti-VCAM1 anticorps

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp VCAM1 est non-conjugé

Application: Flow Cytometry (FACS)

Specificité: Mouse CD106, Mr 100-110 kDa

Attributs du produit: Rat Anti-Mouse CD106-UNLB

Purification: Purified

Immunogène: BALB/3T3 and +/+2.4 cells

Clone: M-K-2

Isotype: IgG1

Information d'application

Indications d'application:

• Applications: FC - Quality tested , IHC-FS - Reported in literature , IP - Reported in literature , WB - Reported in literature , Adhesion - Reported in literature , Block - Reported in literature
• Working Dilutions: Flow Cytometry FITC and BIOT conjugates 1 g/106 cells PE conjugate 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L

Volume d'échantillon: 1 mL

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Agent conservateur: Without preservative

Conseil sur la manipulation: Each reagent is stable for the period shown on the bottle label if stored as directed.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C

Références pour anticorps anti-VCAM1 (ABIN135070)

Wang, Cao, Gorshkov, Zhou, Yang, Xu, Ma, Zhang, Wang, Mao, Zeng, Su, Verin, Hong, Liu, Huo: "Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia." dans: Pharmacological research, Vol. 146, pp. 104292, (2020) (PubMed).

Xu, Wang, Yan, Yang, Zhou, Zeng, Liu, An, Toque, Dong, Jiang, Fulton, Weintraub, Li, Bagi, Hong, Boison, Wu, Huo: "Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation." dans: Nature communications, Vol. 8, Issue 1, pp. 943, (2018) (PubMed).

Siler, Berlow, Kukino, Davis, Nelson, Grafe, Ono, Cetas, Pike, Alkayed: "Soluble Epoxide Hydrolase in Hydrocephalus, Cerebral Edema, and Vascular Inflammation After Subarachnoid Hemorrhage." dans: Stroke, Vol. 46, Issue 7, pp. 1916-22, (2015) (PubMed).

Détails sur VCAM1

Antigène: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Autre désignation: CD106 (VCAM1 Produits)

Synonymes: anticorps CD106, anticorps INCAM-100, anticorps Vcam-1, anticorps VCAM1B, anticorps fi76d06, anticorps wu:fi76d06, anticorps zgc:158875, anticorps VCAM1, anticorps vascular cell adhesion molecule 1, anticorps vascular cell adhesion molecule 1b, anticorps VCAM1, anticorps Vcam1, anticorps vcam1b, anticorps VCAM-1

Sujet: VCAM-1 is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (i.e., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein.

Pathways: Carbohydrate Homeostasis